SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rsv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 11 SER A  61
VAL A  62
GLY A  63
LEU A  41
GLY A  26
 None
 1.41A 1iolA-2rsvA:
undetectable		 1iolA-2rsvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		4 / 6 VAL A 154
THR A 153
LEU A 255
PHE A 149
 None
 1.02A 1s8fB-2rsvA:
undetectable		 1s8fB-2rsvA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		4 / 7 PHE A 290
LEU A 155
VAL A 154
ILE A 252
 None
 0.85A 1t87B-2rsvA:
undetectable		 1t87B-2rsvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		4 / 7 TYR A  87
TYR A 198
HIS A 171
TYR A 173
 None
 1.25A 2ombC-2rsvA:
undetectable
2ombD-2rsvA:
undetectable		 2ombC-2rsvA:
19.90
2ombD-2rsvA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		4 / 5 LEU A 155
GLN A 326
LEU A 324
GLU A 298
 None
 1.12A 3h5gA-2rsvA:
undetectable
3h5gB-2rsvA:
undetectable		 3h5gA-2rsvA:
6.76
3h5gB-2rsvA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 9 VAL A  70
ILE A  29
PHE A  23
ALA A  24
VAL A  62
 None
 1.25A 3me6C-2rsvA:
undetectable		 3me6C-2rsvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		4 / 7 LEU A 165
VAL A 154
LEU A 157
SER A 158
 None
 0.70A 3r9vA-2rsvA:
2.7
3r9vB-2rsvA:
2.0		 3r9vA-2rsvA:
19.95
3r9vB-2rsvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		3 / 3 ASN A 182
LEU A 165
PHE A 227
 None
 0.64A 4dajB-2rsvA:
3.1		 4dajB-2rsvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 9 SER A 181
ASN A 182
GLY A 223
THR A 224
ASP A 197
 None
 1.36A 4fxsA-2rsvA:
undetectable		 4fxsA-2rsvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 8 GLY A  46
LYS A  71
MET A 131
ASP A 137
LEU A 184
 None
 1.04A 4l9iB-2rsvA:
14.9		 4l9iB-2rsvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 8 GLY A  47
LYS A  71
MET A 131
ASP A 137
LEU A 184
 None
 1.15A 4l9iB-2rsvA:
14.9		 4l9iB-2rsvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 7 TYR A  52
VAL A  70
ILE A 130
VAL A  39
ALA A  54
 None
 1.49A 5ospA-2rsvA:
16.1		 5ospA-2rsvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		5 / 12 LEU A 309
LEU A 155
ILE A 323
MET A 251
LEU A 183
 None
 1.17A 5y2tA-2rsvA:
undetectable		 5y2tA-2rsvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens) 		4 / 6 PRO A 111
ILE A 168
GLY A 109
TYR A 167
 None
 0.89A 6gqiA-2rsvA:
undetectable		 6gqiA-2rsvA:
22.20