SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rsy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_1 (DIPEPTIDYL PEPTIDASE IV)	2rsy	PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-EN RICHED MICRODOMAINS 1 TYROSINE-PROTEIN KINASE CSK (Rattus norvegicus)	5 / 12	GLU A 127 SER B 292 TYR A 129 ASN B 318 VAL B 317	None	1.45A	1x70A-2rsyA: undetectable	1x70A-2rsyA: 8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_B_715B801_1 (DIPEPTIDYL PEPTIDASE IV)	2rsy	PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-EN RICHED MICRODOMAINS 1 TYROSINE-PROTEIN KINASE CSK (Rattus norvegicus)	5 / 12	GLU A 127 SER B 292 TYR A 129 ASN B 318 VAL B 317	None	1.46A	1x70B-2rsyA: undetectable	1x70B-2rsyA: 8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JN3_A_JN3A130_2 (FATTY ACID-BINDING PROTEIN, LIVER)	2rsy	TYROSINE-PROTEIN KINASE CSK (Rattus norvegicus)	4 / 7	PHE A 83 LEU A 149 LEU A 152 ARG A 107	None None None PTR B 314 ( 4.4A)	0.99A	2jn3A-2rsyA: undetectable	2jn3A-2rsyA: 20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MZE_A_CFXA364_2 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACA)	2rsy	PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-EN RICHED MICRODOMAINS 1 TYROSINE-PROTEIN KINASE CSK (Rattus norvegicus)	3 / 3	SER B 293 SER B 292 HIS A 128	None	0.71A	3mzeA-2rsyB: undetectable	3mzeA-2rsyB: 8.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1X70_A_715A801_1","DIPEPTIDYL PEPTIDASE IV","2rsy","PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1;TYROSINE-PROTEIN KINASE CSK","Rattus norvegicus",5,"GLU A 127;SER B 292;TYR A 129;ASN B 318;VAL B 317","None","1.45A","1x70A-2rsyA:undetectable","1x70A-2rsyA:8.49"],["1X70_B_715B801_1","DIPEPTIDYL PEPTIDASE IV","2rsy","PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1;TYROSINE-PROTEIN KINASE CSK","Rattus norvegicus",5,"GLU A 127;SER B 292;TYR A 129;ASN B 318;VAL B 317","None","1.46A","1x70B-2rsyA:undetectable","1x70B-2rsyA:8.49"],["2JN3_A_JN3A130_2","FATTY ACID-BINDING PROTEIN, LIVER","2rsy","TYROSINE-PROTEIN KINASE CSK","Rattus norvegicus",4,"PHE A  83;LEU A 149;LEU A 152;ARG A 107","None;None;None;PTR B 314 ( 4.4A)","0.99A","2jn3A-2rsyA:undetectable","2jn3A-2rsyA:20.61"],["3MZE_A_CFXA364_2","D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACA","2rsy","PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1;TYROSINE-PROTEIN KINASE CSK","Rattus norvegicus",3,"SER B 293;SER B 292;HIS A 128","None","0.71A","3mzeA-2rsyB:undetectable","3mzeA-2rsyB:8.82"]]