SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 226
GLY A 230
LEU A 261
ALA A 253
PHE A 245
 None
 1.05A 1dfoA-2rt3A:
undetectable		 1dfoA-2rt3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 226
GLY A 230
LEU A 261
ALA A 253
PHE A 245
 None
 1.05A 1dfoB-2rt3A:
undetectable		 1dfoB-2rt3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 226
GLY A 230
LEU A 261
ALA A 253
PHE A 245
 None
 1.05A 1dfoC-2rt3A:
undetectable		 1dfoC-2rt3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 226
GLY A 230
LEU A 261
ALA A 253
PHE A 245
 None
 1.05A 1dfoD-2rt3A:
undetectable		 1dfoD-2rt3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 235
VAL A 246
LEU A 210
VAL A 208
LEU A 261
 None
 0.94A 2aw1A-2rt3A:
undetectable		 2aw1A-2rt3A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL A 208
LEU A 283
ILE A 222
ILE A 272
 None
 0.90A 3gcsA-2rt3A:
undetectable		 3gcsA-2rt3A:
15.68