SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A3595
SER A3594
LEU A3515
PHE A3629
ILE A3628
 None
 1.13A 1g5yC-2rt5A:
undetectable		 1g5yC-2rt5A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A3533
ALA A3534
LEU A3576
VAL A3660
TYR A3573
 None
 1.26A 1s9pB-2rt5A:
undetectable		 1s9pB-2rt5A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A3533
LEU A3576
VAL A3660
TYR A3573
LEU A3642
 None
 1.26A 1s9pB-2rt5A:
undetectable		 1s9pB-2rt5A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 9 LEU A3639
LEU A3575
VAL A3563
LEU A3555
GLN A3627
 None
 1.29A 1tbfA-2rt5A:
undetectable		 1tbfA-2rt5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 GLN A3627
PHE A3629
PHE A3634
GLY A3562
 None
 0.72A 2qmzA-2rt5A:
undetectable
2qmzB-2rt5A:
undetectable		 2qmzA-2rt5A:
20.64
2qmzB-2rt5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 ILE A3600
HIS A3656
PRO A3580
LEU A3595
 None
 1.11A 3oi8A-2rt5A:
undetectable		 3oi8A-2rt5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A3642
SER A3637
LEU A3647
LEU A3575
 None
 1.25A 4n09B-2rt5A:
undetectable		 4n09B-2rt5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A3642
SER A3637
LEU A3647
LEU A3575
 None
 1.25A 4n09D-2rt5A:
undetectable		 4n09D-2rt5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 9 PHE A3634
SER A3637
VAL A3660
VAL A3563
LEU A3575
 None
 1.40A 4wnvA-2rt5A:
undetectable		 4wnvA-2rt5A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2rt5 MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 PHE A3599
PRO A3546
LEU A3513
VAL A3522
GLN A3591
 None
 1.26A 5im2A-2rt5A:
undetectable		 5im2A-2rt5A:
19.46