SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ
(Escherichia
coli) 		5 / 11 THR A 100
LEU A  91
VAL A  92
SER A  46
ILE A   2
 None
 1.08A 2zbzA-2rtxA:
undetectable		 2zbzA-2rtxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ
(Escherichia
coli) 		5 / 12 ILE A   2
LEU A  48
ILE A  43
ILE A  72
PHE A  41
 None
 1.10A 3b2rA-2rtxA:
undetectable		 3b2rA-2rtxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ
(Escherichia
coli) 		5 / 11 ILE A   2
LEU A  48
ILE A  43
ILE A  72
PHE A  41
 None
 1.10A 3b2rB-2rtxA:
undetectable		 3b2rB-2rtxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ
(Escherichia
coli) 		5 / 12 ALA A  93
ILE A   4
ILE A  10
SER A  46
LEU A  15
 None
 1.14A 3k2hB-2rtxA:
undetectable		 3k2hB-2rtxA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ
(Escherichia
coli) 		4 / 8 SER A  46
ILE A  43
LEU A  91
ILE A  95
 None
 0.83A 4dtaB-2rtxA:
undetectable		 4dtaB-2rtxA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ
(Escherichia
coli) 		4 / 8 HIS A  61
HIS A  62
GLY A 115
SER A 113
 None
 0.88A 5m8rC-2rtxA:
undetectable		 5m8rC-2rtxA:
14.94