SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ru4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct)
5 / 12 ALA B 155
GLY B 157
GLU B 191
ARG A  23
LEU B 196
None
0.89A 1mj2A-2ru4B:
undetectable
1mj2B-2ru4B:
undetectable
1mj2A-2ru4B:
24.30
1mj2B-2ru4B:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct)
5 / 12 LEU B 144
LEU A 106
ALA B 150
ILE B 154
LEU B 174
None
1.09A 1tw4A-2ru4B:
undetectable
1tw4A-2ru4B:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct)
4 / 4 LEU B 132
SER B 152
LEU A 109
LEU A 106
None
1.00A 1yajA-2ru4B:
undetectable
1yajA-2ru4B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct)
4 / 5 LEU B 132
LEU A  94
LEU A  90
LEU B 135
None
0.95A 1yajD-2ru4B:
undetectable
1yajD-2ru4B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.02A 3ln1D-2ru4A:
undetectable
3ln1D-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 GLY A  73
SER A  26
GLY A 115
LEU A  29
ASP A  31
None
1.40A 3r24A-2ru4A:
undetectable
3r24A-2ru4A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 10 ASP A  83
VAL A  81
GLY A  85
ALA A  86
ALA A  89
None
0.93A 3ucjA-2ru4A:
undetectable
3ucjA-2ru4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 11 ALA B 150
LEU A 109
ILE A  82
LEU B 132
GLY B 127
None
0.96A 3zosA-2ru4B:
undetectable
3zosB-2ru4B:
undetectable
3zosA-2ru4B:
15.03
3zosB-2ru4B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.88A 4coxA-2ru4A:
undetectable
4coxA-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.88A 4coxB-2ru4A:
undetectable
4coxB-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 LEU A  90
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.08A 4coxC-2ru4A:
undetectable
4coxC-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.87A 4coxC-2ru4A:
undetectable
4coxC-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.88A 4coxD-2ru4A:
undetectable
4coxD-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 11 ALA A 108
GLY A  74
ILE A 112
GLU A  34
ASN A 111
None
1.10A 4dcmA-2ru4A:
undetectable
4dcmA-2ru4A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct)
6 / 12 GLY A 115
GLY B 116
ASN A  33
LEU A  29
ASP A  31
GLY A  32
None
1.35A 4fp9D-2ru4A:
undetectable
4fp9D-2ru4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
4 / 8 GLY A  73
GLY A  32
ILE A  36
GLU A  34
None
0.77A 4mwzB-2ru4A:
undetectable
4mwzB-2ru4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.01A 4otyA-2ru4A:
undetectable
4otyA-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.99A 4otyB-2ru4A:
undetectable
4otyB-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.97A 4rrwA-2ru4A:
undetectable
4rrwA-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.99A 4rrwB-2ru4A:
undetectable
4rrwB-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.97A 4rrwC-2ru4A:
undetectable
4rrwC-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.94A 4rrwD-2ru4A:
undetectable
4rrwD-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.97A 4rrzA-2ru4A:
undetectable
4rrzA-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.99A 4rrzB-2ru4A:
undetectable
4rrzB-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.97A 4rrzC-2ru4A:
undetectable
4rrzC-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
0.94A 4rrzD-2ru4A:
undetectable
4rrzD-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.00A 5ikrA-2ru4A:
undetectable
5ikrA-2ru4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2
ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII

(synthetic
construct;
synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.07A 5iktA-2ru4A:
undetectable
5iktA-2ru4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2

(synthetic
construct)
5 / 12 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.00A 5kirB-2ru4A:
undetectable
5kirB-2ru4A:
12.72