SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2rug CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 3
(Homo
sapiens) 		5 / 12 GLY A 465
LEU A 467
LEU A 489
VAL A 443
ALA A 499
 None
 1.20A 1gseA-2rugA:
undetectable		 1gseA-2rugA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2rug CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLN A 526
ILE A 527
TYR A 512
 None
 0.74A 1vifA-2rugA:
undetectable		 1vifA-2rugA:
20.20