SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 7 VAL A 110
VAL A  94
TYR A 148
ARG A 196
 None
 1.24A 1t46A-2ruiA:
undetectable		 1t46A-2ruiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 8 VAL A 199
TYR A 197
VAL A 160
ILE A 147
LEU A  90
 None
 1.45A 4jq1B-2ruiA:
undetectable		 4jq1B-2ruiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 9 VAL A 199
TYR A 197
VAL A 160
ILE A 147
LEU A  90
 None
 1.50A 4jqaA-2ruiA:
0.0		 4jqaA-2ruiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 6 SER A  87
GLY A 201
ASP A 202
GLY A 162
 None
 1.05A 4koeA-2ruiA:
undetectable
4koeB-2ruiA:
undetectable
4koeC-2ruiA:
undetectable		 4koeA-2ruiA:
17.21
4koeB-2ruiA:
17.21
4koeC-2ruiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 6 GLY A 201
ASP A 202
GLY A 162
SER A  87
 None
 1.01A 4z53A-2ruiA:
undetectable
4z53B-2ruiA:
undetectable		 4z53A-2ruiA:
14.18
4z53B-2ruiA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2rui LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 SER A 140
ALA A 139
THR A 186
 None
 0.75A 5n0xB-2ruiA:
undetectable		 5n0xB-2ruiA:
17.48