SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DVX_B_DIFB125_2 (TRANSTHYRETIN)	2rv8	DNA-BINDING RESPONSE REGULATOR (Mycobacterium tuberculosis)	4 / 7	LEU A 174 SER A 175 THR A 177 VAL A 202	None	0.96A	1dvxB-2rv8A: undetectable	1dvxB-2rv8A: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_B_9CRB600_2 (RETINOIC ACID RECEPTOR, BETA)	2rv8	DNA-BINDING RESPONSE REGULATOR (Mycobacterium tuberculosis)	3 / 3	LEU A 243 PHE A 185 ARG A 237	None	0.86A	1xdkB-2rv8A: undetectable	1xdkB-2rv8A: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2V_A_BZ1A302_2 (CARBONIC ANHYDRASE 2)	2rv8	DNA-BINDING RESPONSE REGULATOR (Mycobacterium tuberculosis)	3 / 3	HIS A 201 VAL A 218 LEU A 181	None	0.57A	4m2vA-2rv8A: undetectable	4m2vA-2rv8A: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_C_CHDC307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	2rv8	DNA-BINDING RESPONSE REGULATOR (Mycobacterium tuberculosis)	4 / 6	LYS A 167 PHE A 153 LEU A 158 PHE A 179	None	1.24A	6nmpC-2rv8A: undetectable 6nmpJ-2rv8A: undetectable	6nmpC-2rv8A: 17.31 6nmpJ-2rv8A: 19.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DVX_B_DIFB125_2","TRANSTHYRETIN","2rv8","DNA-BINDING RESPONSE REGULATOR","Mycobacterium tuberculosis",4,"LEU A 174;SER A 175;THR A 177;VAL A 202","None","0.96A","1dvxB-2rv8A:undetectable","1dvxB-2rv8A:22.06"],["1XDK_B_9CRB600_2","RETINOIC ACID RECEPTOR, BETA","2rv8","DNA-BINDING RESPONSE REGULATOR","Mycobacterium tuberculosis",3,"LEU A 243;PHE A 185;ARG A 237","None","0.86A","1xdkB-2rv8A:undetectable","1xdkB-2rv8A:18.86"],["4M2V_A_BZ1A302_2","CARBONIC ANHYDRASE 2","2rv8","DNA-BINDING RESPONSE REGULATOR","Mycobacterium tuberculosis",3,"HIS A 201;VAL A 218;LEU A 181","None","0.57A","4m2vA-2rv8A:undetectable","4m2vA-2rv8A:20.89"],["6NMP_C_CHDC307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","2rv8","DNA-BINDING RESPONSE REGULATOR","Mycobacterium tuberculosis",4,"LYS A 167;PHE A 153;LEU A 158;PHE A 179","None","1.24A","6nmpC-2rv8A:undetectable;6nmpJ-2rv8A:undetectable","6nmpC-2rv8A:17.31;6nmpJ-2rv8A:19.27"]]