SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2rvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.78A 3fl9A-2rvjA:
undetectable		 3fl9A-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.84A 3fl9B-2rvjA:
undetectable		 3fl9B-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.86A 3fl9C-2rvjA:
undetectable		 3fl9C-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 9 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.81A 3fl9D-2rvjA:
undetectable		 3fl9D-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.87A 3fl9E-2rvjA:
undetectable		 3fl9E-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.85A 3fl9F-2rvjA:
undetectable		 3fl9F-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
 None
 0.86A 3fl9G-2rvjA:
undetectable		 3fl9G-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 459
LEU A 462
ASP A 463
 None
 0.22A 3ko0A-2rvjA:
undetectable		 3ko0A-2rvjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 459
LEU A 462
ASP A 463
 None
 0.34A 3ko0T-2rvjA:
undetectable		 3ko0T-2rvjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A 520
MET A 513
LEU A 465
ILE A 493
 None
 0.90A 3rfmA-2rvjA:
undetectable		 3rfmA-2rvjA:
15.20