SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2sas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN
(Branchiostoma
lanceolatum) 		5 / 12 LEU A  18
LEU A 169
LEU A  99
PRO A 100
TYR A 165
 None
 1.30A 1p33A-2sasA:
undetectable		 1p33A-2sasA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN
(Branchiostoma
lanceolatum) 		4 / 6 MET A  54
LEU A  58
PHE A  31
MET A  34
 None
 0.98A 1x8vA-2sasA:
undetectable		 1x8vA-2sasA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN
(Branchiostoma
lanceolatum) 		4 / 8 LEU A 169
TYR A 161
TYR A 165
PHE A  17
 None
 0.96A 3i45A-2sasA:
undetectable		 3i45A-2sasA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN
(Branchiostoma
lanceolatum) 		5 / 8 ILE A  26
LEU A  18
ALA A  69
VAL A  77
MET A  85
 None
 1.38A 4rjdA-2sasA:
5.2		 4rjdA-2sasA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN
(Branchiostoma
lanceolatum) 		5 / 12 ASP A  30
ASP A  33
ASP A  19
PHE A  14
ILE A  26
 CA  A 186 ( 2.1A)
None
CA  A 186 ( 3.1A)
None
None
 1.32A 4wh5A-2sasA:
undetectable		 4wh5A-2sasA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN
(Branchiostoma
lanceolatum) 		3 / 3 GLU A  32
TRP A  62
ASN A  21
 None
None
CA  A 186 ( 2.7A)
 1.11A 5dv4A-2sasA:
undetectable		 5dv4A-2sasA:
18.52