SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2sfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 11 HIS A  71
ILE A  69
TRP A  43
LEU A  31
GLY A  18
 None
 1.32A 1axwB-2sfaA:
undetectable		 1axwB-2sfaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 12 GLY A 148
GLY A 107
GLN A 177
ASP A  65
SER A 162
 None
 1.21A 1wg8A-2sfaA:
undetectable		 1wg8A-2sfaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 11 LEU A 135
ASN A  64
LEU A 151
THR A 118
LEU A 120
 None
 1.20A 3a50C-2sfaA:
undetectable		 3a50C-2sfaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		3 / 3 GLY A 149
GLY A   3
GLY A  18
 None
 0.37A 3bogC-2sfaA:
undetectable		 3bogC-2sfaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 12 GLY A  34
LEU A 183
ILE A   7
VAL A 179
ILE A 190
 None
 1.00A 3frqB-2sfaA:
undetectable		 3frqB-2sfaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 12 ILE A  91
ALA A  94
LEU A 183
LEU A 160
LEU A  17
 None
 1.13A 3ix9A-2sfaA:
undetectable		 3ix9A-2sfaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 12 ILE A  91
ALA A  94
LEU A 183
LEU A 160
LEU A  17
 None
 1.17A 3ix9B-2sfaA:
undetectable		 3ix9B-2sfaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		4 / 6 SER A 147
VAL A 132
THR A 174
THR A 173
 None
 0.99A 3tneA-2sfaA:
undetectable		 3tneA-2sfaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 11 PHE A 176
GLN A 137
ALA A 122
LEU A 135
VAL A 132
 None
 1.13A 4g1bB-2sfaA:
undetectable		 4g1bB-2sfaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		4 / 5 TYR A   8
ARG A  14
ASP A 146
GLU A   5
 None
 1.45A 4nkvB-2sfaA:
undetectable		 4nkvB-2sfaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		4 / 4 VAL A 140
ALA A 142
PHE A 176
THR A 161
 None
 1.43A 4z4fA-2sfaA:
undetectable		 4z4fA-2sfaA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		4 / 4 VAL A 140
ALA A 142
PHE A 176
THR A 161
 None
 1.44A 4z4hA-2sfaA:
undetectable		 4z4hA-2sfaA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 9 THR A  32
GLY A  18
ALA A  30
GLU A   5
SER A 108
 None
 0.90A 5vw4A-2sfaA:
undetectable		 5vw4A-2sfaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		5 / 8 THR A  32
GLY A  18
ALA A  30
GLU A   5
SER A 108
 None
 0.89A 5vw9A-2sfaA:
undetectable		 5vw9A-2sfaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		4 / 5 ALA A   6
SER A  16
GLY A 107
TYR A  84
 None
 1.21A 5yodB-2sfaA:
10.0		 5yodB-2sfaA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		4 / 5 ALA A   6
SER A  16
GLY A 107
TYR A  84
 None
 1.13A 5yodD-2sfaA:
6.8		 5yodD-2sfaA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2sfa SERINE PROTEINASE
(Streptomyces
fradiae) 		6 / 12 LEU A  31
GLY A   4
GLY A 149
ILE A   7
PHE A 152
ILE A   1
 None
 1.45A 6ecxA-2sfaA:
undetectable		 6ecxA-2sfaA:
20.32