SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2spt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 8 ASP A 119
TRP A 126
TYR A 128
ARG A 135
 None
 0.78A 1ceaA-2sptA:
undetectable
1ceaB-2sptA:
16.9		 1ceaA-2sptA:
37.93
1ceaB-2sptA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 7 ASP A 119
TRP A 126
TYR A 128
ARG A 135
 None
 0.64A 1ceaB-2sptA:
16.9		 1ceaB-2sptA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 7 ASP A 119
TRP A 126
TYR A 128
ARG A 135
 None
 0.59A 1cebA-2sptA:
16.5		 1cebA-2sptA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 7 ASP A 119
TRP A 126
TYR A 128
ARG A 135
 None
 0.78A 1cebB-2sptA:
16.8		 1cebB-2sptA:
37.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2spt PROTHROMBIN
(Bos
taurus) 		3 / 3 GLN A  88
HIS A  96
PRO A 132
 None
 0.98A 1d8cA-2sptA:
undetectable		 1d8cA-2sptA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2spt PROTHROMBIN
(Bos
taurus) 		3 / 3 LEU A  58
ASN A  53
ARG A  52
 None
 0.72A 2qhfA-2sptA:
undetectable		 2qhfA-2sptA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 6 GLU A 138
GLY A  64
ARG A  75
GLY A  76
 None
 0.88A 5cdnR-2sptA:
undetectable
5cdnS-2sptA:
undetectable		 5cdnR-2sptA:
14.62
5cdnS-2sptA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 5 VAL A 143
PRO A 125
GLY A  71
TYR A  74
 None
 1.36A 5x80A-2sptA:
undetectable
5x80B-2sptA:
undetectable		 5x80A-2sptA:
22.44
5x80B-2sptA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2spt PROTHROMBIN
(Bos
taurus) 		4 / 5 PRO A 125
GLY A  71
TYR A  74
VAL A 143
 None
 1.40A 5x80C-2sptA:
undetectable
5x80D-2sptA:
undetectable		 5x80C-2sptA:
22.44
5x80D-2sptA:
22.44