SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2sxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2sxl SEX-LETHAL PROTEIN
(Drosophila
melanogaster) 		4 / 8 TYR A  47
LEU A  11
TYR A  45
GLY A  42
 None
 0.83A 3jusB-2sxlA:
undetectable		 3jusB-2sxlA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 2sxl SEX-LETHAL PROTEIN
(Drosophila
melanogaster) 		3 / 3 ASN A  31
ASP A  51
ASN A   3
 None
 0.71A 4agaA-2sxlA:
undetectable		 4agaA-2sxlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2sxl SEX-LETHAL PROTEIN
(Drosophila
melanogaster) 		4 / 5 ARG A  37
MET A  15
THR A  16
LEU A  20
 None
 1.36A 5x1bJ-2sxlA:
undetectable		 5x1bJ-2sxlA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2sxl SEX-LETHAL PROTEIN
(Drosophila
melanogaster) 		4 / 5 ARG A  37
MET A  15
THR A  16
LEU A  20
 None
 1.08A 5x1bW-2sxlA:
undetectable		 5x1bW-2sxlA:
19.78