SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2tbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
4 / 7 TYR A 155
THR A 228
SER A 226
GLN A 133
None
1.40A 1eiiA-2tbvA:
undetectable
1eiiA-2tbvA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
4 / 7 LEU A 132
THR A 243
LEU A 239
VAL A 176
None
0.83A 1ictD-2tbvA:
undetectable
1ictD-2tbvA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
3 / 3 LEU A 239
LEU A 132
SER A 131
None
0.68A 1tlmA-2tbvA:
undetectable
1tlmA-2tbvA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
5 / 12 LEU A 263
LEU A 145
SER A 143
THR A 269
ARG A 378
None
1.30A 2oipB-2tbvA:
undetectable
2oipB-2tbvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
4 / 6 THR A 216
PHE A 180
LEU A 134
ASP A 183
None
None
None
CA  A 388 (-3.9A)
1.12A 2wm3A-2tbvA:
undetectable
2wm3A-2tbvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
5 / 12 LEU A 263
LEU A 145
SER A 143
THR A 269
ARG A 378
None
1.20A 3hj3C-2tbvA:
undetectable
3hj3C-2tbvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
4 / 8 LEU A 374
TYR A 349
PHE A 364
LEU A 302
None
1.01A 3i45A-2tbvA:
undetectable
3i45A-2tbvA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
3 / 3 ASP A 183
LYS A 182
ASP A 181
CA  A 388 (-3.9A)
None
CA  A 390 (-2.4A)
0.42A 4a7tA-2tbvA:
undetectable
4a7tA-2tbvA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
4 / 8 ASN A 342
ALA A 346
SER A 347
ARG A 319
None
1.17A 4ijiF-2tbvA:
undetectable
4ijiF-2tbvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
4 / 6 ALA A 149
PRO A 136
PHE A 142
GLU A 110
None
1.20A 5odqA-2tbvA:
undetectable
5odqA-2tbvA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
5 / 11 LEU A 293
GLY A 291
GLY A 289
LEU A 314
SER A 315
None
0.86A 5twjD-2tbvA:
undetectable
5twjD-2tbvA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
5 / 12 LEU A 257
GLY A 139
PRO A 136
PRO A 290
PHE A 312
None
1.31A 5x6yA-2tbvA:
undetectable
5x6yA-2tbvA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)
2tbv TOMATO BUSHY STUNT
VIRUS

(Tomato
bushy
stunt
virus)
3 / 3 LEU A 145
SER A 143
PHE A 142
None
0.61A 6fgcA-2tbvA:
undetectable
6fgcA-2tbvA:
23.30