SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2tmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  53
GLU A 149
ARG A  41
SER A  98
TYR A 102
 ATM  A 217 ( 4.7A)
ATM  A 217 ( 4.9A)
ATM  A 217 (-4.0A)
ATM  A 217 ( 4.8A)
ATM  A 217 (-3.4A)
 1.46A 3apvB-2tmkA:
undetectable		 3apvB-2tmkA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 171
LEU A 168
ASP A 169
 None
 0.40A 3ko0A-2tmkA:
undetectable		 3ko0A-2tmkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 171
LEU A 168
ASP A 169
 None
 0.44A 3ko0T-2tmkA:
undetectable		 3ko0T-2tmkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 149
ARG A 150
PHE A  69
PRO A  39
 ATM  A 217 ( 4.9A)
None
ATM  A 217 (-3.5A)
ATM  A 217 ( 4.2A)
 1.40A 3ql6A-2tmkA:
undetectable		 3ql6A-2tmkA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 148
ARG A  15
LYS A 146
 None
 1.20A 3wipG-2tmkA:
undetectable		 3wipG-2tmkA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  32
LEU A 204
ASN A  89
ILE A   8
 None
 1.03A 4k0bA-2tmkA:
undetectable		 4k0bA-2tmkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  32
LEU A 204
ASN A  89
ILE A   8
 None
 0.98A 4l7iA-2tmkA:
undetectable		 4l7iA-2tmkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  14
SER A  98
TYR A 102
 ATM  A 217 ( 3.0A)
ATM  A 217 ( 4.8A)
ATM  A 217 (-3.4A)
 0.74A 5glmA-2tmkA:
undetectable		 5glmA-2tmkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  51
TYR A  52
ARG A 150
 None
 0.43A 5uunA-2tmkA:
undetectable		 5uunA-2tmkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  51
TYR A  52
ARG A 150
 None
 0.38A 5uunB-2tmkA:
undetectable		 5uunB-2tmkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2tmk THYMIDYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 124
SER A 214
PHE A 213
 None
 0.66A 6fgcA-2tmkA:
undetectable		 6fgcA-2tmkA:
17.14