SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2tnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		4 / 5 VAL A  58
TYR A  56
VAL A  50
ASP A 130
 None
 1.19A 2x45A-2tnfA:
undetectable		 2x45A-2tnfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		4 / 5 VAL A  58
TYR A  56
VAL A  50
ASP A 130
 None
 1.30A 2x45C-2tnfA:
undetectable		 2x45C-2tnfA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		4 / 7 PHE A 152
LEU A  48
LEU A  37
LEU A  43
 None
 0.87A 3bgdB-2tnfA:
undetectable		 3bgdB-2tnfA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		3 / 3 GLN A  21
HIS A  20
ARG A  32
 None
 1.18A 4qyqA-2tnfA:
undetectable		 4qyqA-2tnfA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		3 / 3 GLN A  21
HIS A  20
ARG A  32
 None
 1.16A 4qyqB-2tnfA:
undetectable		 4qyqB-2tnfA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		3 / 3 LEU A 132
LEU A 126
ARG A  82
 None
 0.66A 6fgcA-2tnfA:
undetectable		 6fgcA-2tnfA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)
(Mus
musculus) 		3 / 3 LEU A 132
LEU A 126
ARG A  82
 None
 0.61A 6fgdA-2tnfA:
undetectable		 6fgdA-2tnfA:
17.42