SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2tpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 LEU A 284
ARG A 315
TYR A 108
VAL A 303
 None
 1.09A 1db1A-2tptA:
undetectable		 1db1A-2tptA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 PRO A 398
ASP A 394
ASP A 391
 None
 0.50A 1sqfA-2tptA:
undetectable		 1sqfA-2tptA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 PRO A 137
ILE A 112
ASN A 140
LEU A 160
ALA A 193
 None
 1.16A 3a50A-2tptA:
undetectable		 3a50A-2tptA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ARG A   9
LEU A  17
ILE A  34
PHE A  25
 None
 1.24A 3ln1D-2tptA:
undetectable		 3ln1D-2tptA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLU A 194
ILE A 112
SER A 113
GLY A 114
SER A  86
 None
None
SO4  A 441 (-2.7A)
None
SO4  A 441 ( 4.4A)
 0.94A 3r75A-2tptA:
undetectable		 3r75A-2tptA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 GLU A 194
ILE A 112
SER A 113
GLY A 114
SER A  86
 None
None
SO4  A 441 (-2.7A)
None
SO4  A 441 ( 4.4A)
 0.93A 3r75B-2tptA:
undetectable		 3r75B-2tptA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 LEU A 246
ALA A 278
LEU A 238
THR A 240
 None
 1.10A 3rozA-2tptA:
undetectable		 3rozA-2tptA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 4 LEU A 124
GLY A 122
MET A 111
PHE A 133
 None
None
SO4  A 441 ( 4.1A)
None
 1.27A 3vaqB-2tptA:
2.8		 3vaqB-2tptA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		6 / 12 PRO A 137
ILE A 112
LEU A 160
ALA A 193
PRO A 110
ILE A 146
 None
 1.43A 3vrmA-2tptA:
undetectable		 3vrmA-2tptA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 GLY A 206
ALA A 247
GLY A  91
GLU A 258
ASN A 269
 None
 1.28A 4a6nA-2tptA:
2.8		 4a6nA-2tptA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A  98
GLY A  89
GLY A  88
THR A  94
GLY A 116
 None
 0.92A 4dc3B-2tptA:
3.3		 4dc3B-2tptA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 11 THR A  87
LEU A 117
TYR A 168
ARG A 171
VAL A 177
ILE A 183
SER A 186
LYS A 190
MET A 211
LEU A 220
 None
 0.64A 4lhmA-2tptA:
67.7		 4lhmA-2tptA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 LYS A 191
ASN A 229
ASP A  83
 None
 0.90A 4o1eA-2tptA:
undetectable		 4o1eA-2tptA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 LEU A 220
SER A 186
THR A 184
LEU A 182
ILE A 180
 None
 1.34A 4ubsA-2tptA:
undetectable		 4ubsA-2tptA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 LEU A 192
MET A  53
VAL A  57
THR A  60
 None
 0.95A 5e4dA-2tptA:
undetectable
5e4dB-2tptA:
undetectable		 5e4dA-2tptA:
18.18
5e4dB-2tptA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 PHE A 167
THR A 170
TYR A 168
PHE A 210
 None
 1.41A 5lrbA-2tptA:
3.2		 5lrbA-2tptA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 10 VAL A 149
ILE A 145
PHE A 142
GLY A  99
ALA A 103
 None
 1.08A 5mxbA-2tptA:
undetectable		 5mxbA-2tptA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 9 LEU A 220
LEU A 238
VAL A 203
ILE A 187
LEU A 188
 None
 0.97A 5vkqC-2tptA:
undetectable
5vkqD-2tptA:
1.0		 5vkqC-2tptA:
13.60
5vkqD-2tptA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 ILE A  39
ARG A  30
MET A  63
LEU A  59
 None
 1.04A 5z86N-2tptA:
undetectable
5z86W-2tptA:
undetectable		 5z86N-2tptA:
21.13
5z86W-2tptA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 GLY A  28
ASN A  27
ASP A  31
ARG A  30
 None
 1.27A 6dwdB-2tptA:
undetectable
6dwdD-2tptA:
undetectable		 6dwdB-2tptA:
21.81
6dwdD-2tptA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2tpt THYMIDINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 5 ARG A  30
GLY A  28
ASN A  27
ASP A  31
 None
 1.29A 6dwjB-2tptA:
undetectable
6dwjD-2tptA:
undetectable		 6dwjB-2tptA:
21.81
6dwjD-2tptA:
21.81