SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ts1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A  97
GLY A  77
ASN A  89
PRO A  79
 None
 1.24A 1dedA-2ts1A:
undetectable		 1dedA-2ts1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 9 PHE A 231
THR A 258
LEU A 298
VAL A 302
ILE A  46
 None
 1.29A 1gebA-2ts1A:
undetectable		 1gebA-2ts1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A  36
HIS A  45
HIS A  48
GLY A 192
ASP A 194
 None
 0.87A 1jzsA-2ts1A:
undetectable		 1jzsA-2ts1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		6 / 11 GLY A  36
HIS A  48
GLY A 192
ASP A 194
GLN A 195
LEU A 222
 None
 0.74A 1jzsA-2ts1A:
undetectable		 1jzsA-2ts1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A  45
GLY A  47
HIS A  48
GLY A 192
ASP A 194
 None
 0.57A 1pg2A-2ts1A:
9.1		 1pg2A-2ts1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  47
HIS A  48
GLY A 192
ASP A 194
GLN A 195
 None
 0.74A 1qu2A-2ts1A:
4.8		 1qu2A-2ts1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  48
GLY A 192
ASP A 194
GLN A 195
VAL A 223
 None
 0.70A 1qu2A-2ts1A:
4.8		 1qu2A-2ts1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 7 PHE A 231
THR A 258
LEU A 298
VAL A 302
ILE A  46
 None
 1.33A 1t87B-2ts1A:
undetectable		 1t87B-2ts1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 9 PHE A 231
THR A 258
LEU A 298
VAL A 302
ILE A  46
 None
 1.32A 2a1oB-2ts1A:
undetectable		 2a1oB-2ts1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A  34
GLY A  36
THR A  73
GLN A 173
GLN A 195
 None
 0.83A 2akeA-2ts1A:
20.5		 2akeA-2ts1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A  34
GLY A  36
THR A  73
GLN A 173
GLN A 195
 None
 0.80A 2azxA-2ts1A:
20.2		 2azxA-2ts1A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		4 / 7 ASP A  38
GLY A  70
GLY A  71
ASN A 123
 None
 0.75A 2c49B-2ts1A:
undetectable		 2c49B-2ts1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A  45
GLY A  47
HIS A  48
GLY A 192
ASP A 194
 None
 0.67A 2x1lA-2ts1A:
9.5		 2x1lA-2ts1A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  45
GLY A  47
HIS A  48
GLY A 192
ASP A 194
 None
 0.68A 2x1lB-2ts1A:
9.1		 2x1lB-2ts1A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A  45
GLY A  47
HIS A  48
GLY A 192
ASP A 194
 None
 0.73A 2x1lC-2ts1A:
9.3		 2x1lC-2ts1A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 123
TRP A 126
ASP A  38
 None
 0.91A 4a7tA-2ts1A:
undetectable
4a7tF-2ts1A:
undetectable		 4a7tA-2ts1A:
18.44
4a7tF-2ts1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A 220
GLY A 192
GLY A 191
THR A  54
LEU A   7
GLY A  36
 None
 1.18A 4e3aB-2ts1A:
2.6		 4e3aB-2ts1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 172
GLY A 197
ASP A 176
VAL A 139
PHE A 143
 None
 1.22A 4wnwA-2ts1A:
undetectable		 4wnwA-2ts1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A  44
THR A  51
THR A  40
GLY A 192
PHE A  37
 None
 1.44A 5utuF-2ts1A:
undetectable		 5utuF-2ts1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ts1 TYROSYL-TRNA
SYNTHETASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 107
PHE A 270
LEU A 241
 None
 0.92A 5x1bC-2ts1A:
undetectable		 5x1bC-2ts1A:
20.20