SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ucz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 SER A 122
VAL A 123
THR A  74
ILE A  41
PHE A  73
 None
 1.38A 2vdyA-2uczA:
undetectable		 2vdyA-2uczA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 SER A 122
VAL A 123
THR A  74
ILE A  41
PHE A  73
 None
 1.47A 4c49D-2uczA:
undetectable		 4c49D-2uczA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 123
ILE A  41
ILE A  24
ALA A  26
 None
 0.88A 4lv9A-2uczA:
undetectable		 4lv9A-2uczA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  73
ILE A  24
GLY A  43
ILE A  82
VAL A 123
 None
 1.06A 4nkxA-2uczA:
undetectable		 4nkxA-2uczA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  16
LEU A   9
LEU A 120
LEU A  58
ALA A  26
 None
 1.03A 4p65B-2uczA:
undetectable
4p65D-2uczA:
undetectable
4p65G-2uczA:
undetectable
4p65H-2uczA:
undetectable		 4p65B-2uczA:
11.45
4p65D-2uczA:
11.45
4p65G-2uczA:
11.30
4p65H-2uczA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  54
ILE A  77
PRO A  48
LEU A 127
ILE A  90
 None
 1.05A 4pd4C-2uczA:
undetectable		 4pd4C-2uczA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		4 / 4 GLY A  27
VAL A  25
PHE A  54
ILE A  41
 None
 1.09A 4xv2B-2uczA:
undetectable		 4xv2B-2uczA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2ucz UBIQUITIN
CONJUGATING ENZYME
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  24
VAL A  88
LEU A  93
ILE A  90
LEU A  16
 None
 1.44A 5iepA-2uczA:
2.4		 5iepA-2uczA:
22.49