SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 LEU A 184
HIS A 179
ILE A 224
 None
 0.72A 1s9pB-2uu7A:
undetectable		 1s9pB-2uu7A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 8 PHE A  98
GLY A  37
THR A 111
VAL A 101
 None
 0.81A 2a1mB-2uu7A:
undetectable		 2a1mB-2uu7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 5 PRO A 199
PRO A 146
GLY A 148
TYR A 171
 None
 1.17A 2jkjD-2uu7A:
undetectable		 2jkjD-2uu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 5 PRO A 199
PRO A 146
GLY A 148
TYR A 171
 None
 1.17A 2jkjF-2uu7A:
undetectable		 2jkjF-2uu7A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 4 SER A  75
SER A  66
THR A  67
SER A  65
 None
 1.34A 3loqA-2uu7A:
undetectable		 3loqA-2uu7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 GLY A  64
TRP A  32
VAL A 101
 None
 0.77A 3n62B-2uu7A:
undetectable		 3n62B-2uu7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 GLY A  64
TRP A  32
VAL A 101
 None
 0.76A 3n65B-2uu7A:
undetectable		 3n65B-2uu7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 GLY A  64
TRP A  32
VAL A 101
 None
 0.76A 3n66B-2uu7A:
undetectable		 3n66B-2uu7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		5 / 12 GLY A 251
GLY A 249
GLN A 201
ALA A 344
ASN A 345
 None
 1.45A 3t7sC-2uu7A:
undetectable		 3t7sC-2uu7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 7 ILE A  33
THR A 111
VAL A 220
ASP A 213
 None
 1.36A 4iarA-2uu7A:
undetectable		 4iarA-2uu7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.44A 4w5qA-2uu7A:
undetectable		 4w5qA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.45A 4w5qA-2uu7A:
undetectable		 4w5qA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.42A 4w5rA-2uu7A:
undetectable		 4w5rA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.40A 4w5rA-2uu7A:
undetectable		 4w5rA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.45A 4w5tA-2uu7A:
undetectable		 4w5tA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.40A 4w5tA-2uu7A:
undetectable		 4w5tA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.43A 4z4cA-2uu7A:
undetectable		 4z4cA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.40A 4z4cA-2uu7A:
undetectable		 4z4cA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.41A 4z4fA-2uu7A:
undetectable		 4z4fA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.42A 4z4fA-2uu7A:
undetectable		 4z4fA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 5 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.43A 4z4gA-2uu7A:
undetectable		 4z4gA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 5 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.42A 4z4gA-2uu7A:
undetectable		 4z4gA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 250
THR A 237
THR A 138
 None
 1.43A 4z4iA-2uu7A:
undetectable		 4z4iA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 ASP A 239
ALA A 344
THR A 237
THR A 138
 None
 1.43A 4z4iA-2uu7A:
undetectable		 4z4iA-2uu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 7 HIS A 304
LYS A 241
GLY A 245
ASN A 246
 None
 0.99A 5a5zC-2uu7A:
undetectable		 5a5zC-2uu7A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 ASN A 112
ASP A 216
GLY A 215
 None
 0.67A 5fctB-2uu7A:
undetectable		 5fctB-2uu7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		5 / 12 LEU A 300
GLY A 249
GLU A 136
GLY A 251
ARG A 340
 None
None
MG  A 401 (-3.5A)
None
None
 1.26A 5o4yD-2uu7A:
undetectable
5o4yE-2uu7A:
undetectable		 5o4yD-2uu7A:
3.85
5o4yE-2uu7A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 GLY A  64
TRP A  32
VAL A 101
 None
 0.74A 5vuoB-2uu7A:
undetectable		 5vuoB-2uu7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 HIS A 253
GLU A 196
ASN A 248
 None
MG  A 401 (-3.2A)
None
 0.92A 5wbvA-2uu7A:
undetectable		 5wbvA-2uu7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		3 / 3 HIS A 253
GLU A 196
ASN A 248
 None
MG  A 401 (-3.2A)
None
 0.93A 5wbvB-2uu7A:
undetectable		 5wbvB-2uu7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2uu7 GLUTAMINE SYNTHETASE
(Canis
lupus) 		4 / 6 MET A  77
GLU A  71
GLY A  35
GLY A  37
 None
 0.81A 5x7pB-2uu7A:
undetectable		 5x7pB-2uu7A:
14.79