SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 12 MET A  20
ILE A 290
PHE A  55
LEU A   8
LEU A 183
 None
 1.06A 1eiiA-2uutA:
undetectable		 1eiiA-2uutA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 12 PHE A 361
HIS A 313
LEU A 241
LEU A 368
TYR A 243
 None
 1.44A 1fm6X-2uutA:
undetectable		 1fm6X-2uutA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.06A 1fohA-2uutA:
undetectable		 1fohA-2uutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.10A 1fohB-2uutA:
undetectable		 1fohB-2uutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.05A 1fohC-2uutA:
undetectable		 1fohC-2uutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.06A 1fohD-2uutA:
undetectable		 1fohD-2uutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.08A 1pn0C-2uutA:
undetectable		 1pn0C-2uutA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.10A 1pn0D-2uutA:
undetectable		 1pn0D-2uutA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 THR A 357
LEU A 368
VAL A 364
VAL A 336
 None
 1.02A 2cppA-2uutA:
undetectable		 2cppA-2uutA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 11 LEU A 262
ILE A 261
ILE A  91
LEU A 206
VAL A 202
 None
 1.02A 2kawA-2uutA:
undetectable		 2kawA-2uutA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 VAL A  75
ALA A 319
PRO A 252
THR A 255
 None
 1.02A 2q6oA-2uutA:
undetectable		 2q6oA-2uutA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		3 / 3 ARG A 295
GLN A   4
PRO A   9
 None
 0.97A 2qhfA-2uutA:
undetectable		 2qhfA-2uutA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 8 LEU A 468
LEU A 441
ALA A 440
PHE A 411
 None
 0.84A 2vcvP-2uutA:
undetectable		 2vcvP-2uutA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 12 LEU A 112
LEU A 145
ALA A 195
SER A 117
GLY A 119
 None
 1.11A 2vmyB-2uutA:
undetectable		 2vmyB-2uutA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		6 / 9 ASP A 247
SER A 300
ASN A 309
TYR A 345
GLY A 346
ASP A 348
 None
 1.11A 3sfuA-2uutA:
38.5		 3sfuA-2uutA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		6 / 9 ASP A 247
ASN A 309
TYR A 345
GLY A 346
ASP A 348
LEU A 387
 None
 0.70A 3sfuB-2uutA:
38.9		 3sfuB-2uutA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 12 GLY A 296
ILE A 315
GLY A  74
ALA A 256
ALA A 257
 None
 1.02A 3sufB-2uutA:
undetectable		 3sufB-2uutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC517_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 11 LYS A  66
GLU A 169
LYS A 175
LYS A 180
ARG A 182
 None
 1.37A 3ur0C-2uutA:
39.1		 3ur0C-2uutA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.14A 4a97E-2uutA:
undetectable		 4a97E-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 8 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.10A 4a97C-2uutA:
undetectable		 4a97C-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 8 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.11A 4a97D-2uutA:
undetectable		 4a97D-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.11A 4a97H-2uutA:
undetectable		 4a97H-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 8 PHE A 337
TYR A  90
VAL A  87
ILE A 261
 None
 1.09A 4a97I-2uutA:
undetectable		 4a97I-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 GLY A 186
ASP A 188
GLY A 119
HIS A 144
 None
 0.92A 4c5nA-2uutA:
undetectable		 4c5nA-2uutA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 8 THR A 357
LEU A 368
VAL A 364
VAL A 336
 None
 1.00A 4l4aA-2uutA:
undetectable		 4l4aA-2uutA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 8 THR A 357
LEU A 368
VAL A 364
VAL A 336
 None
 1.02A 4l4dA-2uutA:
undetectable		 4l4dA-2uutA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 PRO A 172
GLU A 174
GLU A  35
TRP A  32
 None
 1.13A 4uacA-2uutA:
undetectable		 4uacA-2uutA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 4 ALA A 253
VAL A  75
GLY A 372
THR A  72
 None
 1.08A 4ubeA-2uutA:
undetectable		 4ubeA-2uutA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		3 / 3 ASP A 242
ARG A 409
ARG A 171
 None
 0.98A 5eajB-2uutA:
undetectable		 5eajB-2uutA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		3 / 3 VAL A 308
ARG A 295
PRO A 282
 None
 0.81A 5koxA-2uutA:
undetectable		 5koxA-2uutA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 7 ASP A 188
PRO A 120
TYR A 286
SER A 281
 None
 1.10A 5l1fC-2uutA:
undetectable		 5l1fC-2uutA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 5 ASP A 222
ILE A 398
ASN A 472
TYR A 443
 None
 1.20A 6a93B-2uutA:
undetectable		 6a93B-2uutA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		4 / 6 TRP A 185
GLY A  19
ALA A 165
LEU A 164
 None
 1.08A 6fosA-2uutA:
undetectable		 6fosA-2uutA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2uut RNA-DIRECTED RNA
POLYMERASE
(Sapporo
virus) 		5 / 10 TRP A 185
GLY A  18
ALA A 165
LEU A 164
LEU A 259
 None
 1.31A 6hqbA-2uutA:
undetectable
6hqbJ-2uutA:
undetectable		 6hqbA-2uutA:
11.30
6hqbJ-2uutA:
5.43