SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 9 ILE A 216
LEU A 244
MET A 312
ALA A 210
VAL A 200
 None
 1.21A 1ctrA-2uuuA:
undetectable		 1ctrA-2uuuA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 LYS A 102
LEU A 110
LEU A 143
VAL A 190
PHE A  97
 None
 1.10A 1gseA-2uuuA:
undetectable		 1gseA-2uuuA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 TYR A 466
VAL A 505
ILE A 351
ILE A 419
ILE A 400
 None
 1.02A 1oipA-2uuuA:
undetectable		 1oipA-2uuuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 11 ILE A 144
THR A 121
PRO A 141
ALA A 140
VAL A 137
 None
 1.14A 1rv7A-2uuuA:
undetectable
1rv7B-2uuuA:
undetectable		 1rv7A-2uuuA:
12.18
1rv7B-2uuuA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 8 TYR A 445
ASP A 442
TRP A  24
HIS A 496
 None
None
FAD  A1587 (-4.6A)
None
 1.38A 2ha2A-2uuuA:
undetectable		 2ha2A-2uuuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 8 TYR A 445
ASP A 442
TRP A  24
HIS A 496
 None
None
FAD  A1587 (-4.6A)
None
 1.39A 2ha2B-2uuuA:
undetectable		 2ha2B-2uuuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 10 ALA A 160
GLN A 109
LEU A 156
LEU A 101
ARG A 155
 None
 1.18A 2xn6A-2uuuA:
undetectable
2xn6B-2uuuA:
undetectable		 2xn6A-2uuuA:
21.40
2xn6B-2uuuA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 GLY A 277
VAL A 153
ILE A 297
PRO A 169
VAL A 157
 None
None
None
FAD  A1587 (-3.7A)
None
 0.79A 3el5B-2uuuA:
undetectable		 3el5B-2uuuA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 4 ILE A 168
ARG A 127
ILE A 180
THR A 303
 None
None
FAD  A1587 ( 4.9A)
None
 1.18A 3ia4C-2uuuA:
undetectable		 3ia4C-2uuuA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		3 / 3 ARG A 352
GLU A 461
TYR A 501
 None
 0.89A 3k37B-2uuuA:
undetectable		 3k37B-2uuuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 CYH A 581
PRO A 577
THR A 274
THR A 189
 None
 1.47A 3q07A-2uuuA:
undetectable		 3q07A-2uuuA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 CYH A 581
PRO A 577
THR A 274
THR A 189
 None
 1.45A 3q07B-2uuuA:
undetectable		 3q07B-2uuuA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 PHE A 105
GLU A 151
SER A 149
VAL A 145
ILE A 192
 None
 1.28A 3rfaA-2uuuA:
undetectable		 3rfaA-2uuuA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 VAL A 166
VAL A 165
ARG A 187
LYS A  92
 None
 1.25A 3rv5A-2uuuA:
0.0
3rv5B-2uuuA:
undetectable		 3rv5A-2uuuA:
10.76
3rv5B-2uuuA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 ILE A 130
ILE A 525
TYR A 524
GLU A 526
 None
 1.14A 4a99D-2uuuA:
2.1		 4a99D-2uuuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 6 HIS A  12
SER A  -1
GLU A 152
ASP A 108
 None
 1.41A 4blvA-2uuuA:
undetectable		 4blvA-2uuuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		3 / 3 TYR A 441
ARG A 352
HIS A 255
 None
None
FAD  A1587 (-4.3A)
 1.10A 4fubA-2uuuA:
undetectable		 4fubA-2uuuA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 7 ALA A 310
LEU A 248
LEU A 244
TRP A 202
 None
 1.00A 4iomA-2uuuA:
undetectable		 4iomA-2uuuA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 8 ALA A 310
LEU A 248
LEU A 244
TRP A 202
 None
 0.98A 4jjkA-2uuuA:
undetectable		 4jjkA-2uuuA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 LEU A 143
SER A 191
LEU A 146
LEU A 101
 None
 1.33A 4n09D-2uuuA:
undetectable		 4n09D-2uuuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 4 THR A 189
ARG A 187
GLU A 186
VAL A 166
 None
 1.31A 4odoC-2uuuA:
0.0		 4odoC-2uuuA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 GLY A 172
SER A 242
PHE A 241
VAL A 132
LEU A 129
 FAD  A1587 (-3.4A)
FAD  A1587 (-4.6A)
None
None
None
 1.10A 5ergB-2uuuA:
undetectable		 5ergB-2uuuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		3 / 3 VAL A 200
LYS A 313
MET A 266
 None
 1.10A 5nknA-2uuuA:
undetectable		 5nknA-2uuuA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 GLU A 358
GLN A 360
GLU A 357
LEU A 361
GLU A  62
 None
None
None
PL3  A1588 ( 4.6A)
None
 1.16A 5nwuA-2uuuA:
undetectable		 5nwuA-2uuuA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 PHE A 104
ARG A 187
ILE A 192
PHE A  97
ALA A 160
 None
 1.13A 6c2mB-2uuuA:
undetectable		 6c2mB-2uuuA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		4 / 5 ARG A 447
ARG A 133
GLY A  23
ASN A  22
 PL3  A1588 (-3.4A)
None
None
None
 1.40A 6dwjB-2uuuA:
2.9
6dwjD-2uuuA:
3.2		 6dwjB-2uuuA:
22.58
6dwjD-2uuuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE
(Dictyostelium
discoideum) 		5 / 12 SER A 191
ASN A  22
LEU A 129
GLY A 173
ILE A 144
 None
None
None
FAD  A1587 (-3.4A)
None
 1.31A 6dwnA-2uuuA:
undetectable		 6dwnA-2uuuA:
10.06