SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 GLY A 199
GLN A 320
ILE A 312
VAL A 313
 AMP  A1324 ( 4.8A)
None
AMP  A1324 (-3.7A)
None
 1.04A 1rxcC-2uv7A:
undetectable		 1rxcC-2uv7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 GLY A 199
GLN A 320
ILE A 312
VAL A 313
 AMP  A1324 ( 4.8A)
None
AMP  A1324 (-3.7A)
None
 1.04A 1rxcD-2uv7A:
undetectable		 1rxcD-2uv7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 10 GLU A 283
ALA A 321
ILE A 318
LEU A 292
TYR A 201
 None
 1.15A 3fl9A-2uv7A:
undetectable		 3fl9A-2uv7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE A 312
ASP A 317
THR A 200
SER A 226
PRO A 229
 AMP  A1324 (-3.7A)
AMP  A1324 (-2.9A)
AMP  A1324 (-3.0A)
AMP  A1324 (-2.7A)
None
 0.53A 3kpdB-2uv7A:
15.4		 3kpdB-2uv7A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2uv7 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 GLU A 286
LEU A 285
ILE A 288
ARG A 291
VAL A 293
 None
 1.29A 5vlmE-2uv7A:
undetectable		 5vlmE-2uv7A:
21.50