SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 145
LEU G 555
LEU G 267
THR G 252
PHE G 548
 None
 1.49A 1a28A-2uv8G:
undetectable		 1a28A-2uv8G:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.95A 1c6yB-2uv8G:
undetectable		 1c6yB-2uv8G:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.98A 1c8lA-2uv8G:
0.0		 1c8lA-2uv8G:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 LYS G1358
SER G1397
THR G1395
VAL G1393
 None
 0.95A 1dvxB-2uv8G:
undetectable		 1dvxB-2uv8G:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 ARG G1590
ALA G1655
ALA G1598
GLU G1594
 None
 1.15A 1e7bA-2uv8G:
undetectable		 1e7bA-2uv8G:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 ARG G1590
ALA G1655
ALA G1598
GLU G1594
 None
 1.13A 1e7bB-2uv8G:
0.3		 1e7bB-2uv8G:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 THR G 279
ALA G 282
GLU G 285
ILE G 439
LEU G 303
 None
 1.05A 1errA-2uv8G:
undetectable		 1errA-2uv8G:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 502
TYR G 249
PHE G 496
GLY G 269
ALA G 270
 None
 1.07A 1fe2A-2uv8G:
undetectable		 1fe2A-2uv8G:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.94A 1gfzA-2uv8G:
undetectable		 1gfzA-2uv8G:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 LEU G  86
VAL G  22
ILE G  29
VAL G  68
PHE G  64
 None
 1.43A 1gx9A-2uv8G:
0.0		 1gx9A-2uv8G:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 LEU G1931
VAL G1936
GLU G1942
ILE G1922
GLN G1928
 None
 1.15A 1gx9A-2uv8G:
0.0		 1gx9A-2uv8G:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 10 PRO G 506
GLY G 505
LEU G 303
THR G 279
GLY G 276
 None
 1.17A 1h4oA-2uv8G:
undetectable
1h4oB-2uv8G:
undetectable		 1h4oA-2uv8G:
6.39
1h4oB-2uv8G:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 502
TYR G 249
PHE G 496
GLY G 269
ALA G 270
 None
 1.07A 1igxA-2uv8G:
undetectable		 1igxA-2uv8G:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 276
GLY G 161
LEU G 512
THR G 279
ALA G 280
 None
 1.02A 1jg2A-2uv8G:
undetectable		 1jg2A-2uv8G:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 THR G 748
PHE G 767
GLU G 744
GLY G 734
 None
 1.14A 1kqbA-2uv8G:
undetectable
1kqbB-2uv8G:
undetectable		 1kqbA-2uv8G:
7.99
1kqbB-2uv8G:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.96A 1l5qA-2uv8G:
undetectable		 1l5qA-2uv8G:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.97A 1l5qB-2uv8G:
undetectable		 1l5qB-2uv8G:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.98A 1l7xA-2uv8G:
0.0		 1l7xA-2uv8G:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.98A 1l7xB-2uv8G:
undetectable		 1l7xB-2uv8G:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 8 GLY G1356
TYR G1357
SER G1408
HIS G1352
 None
 1.08A 1maaD-2uv8G:
undetectable		 1maaD-2uv8G:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 PHE G 950
LEU G 995
LEU G 914
 None
 0.64A 1mx1E-2uv8G:
undetectable		 1mx1E-2uv8G:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 VAL G 184
GLY G 185
ILE G 244
VAL G 243
 None
 0.74A 1p2yA-2uv8G:
undetectable		 1p2yA-2uv8G:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.96A 1sduB-2uv8G:
undetectable		 1sduB-2uv8G:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 LYS G1358
THR G1407
SER G1397
VAL G1393
 None
 0.78A 1tyrB-2uv8G:
undetectable		 1tyrB-2uv8G:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 6 VAL G 922
LEU G 995
PHE G 946
MET G1006
SER G1005
 None
 1.48A 1wrlB-2uv8G:
undetectable		 1wrlB-2uv8G:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ARG G1567
GLU G1199
SER G1566
VAL G1195
VAL G1182
 None
 1.45A 1x70A-2uv8G:
undetectable		 1x70A-2uv8G:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ARG G1567
GLU G1199
SER G1566
VAL G1195
VAL G1182
 None
 1.44A 1x70B-2uv8G:
undetectable		 1x70B-2uv8G:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 PHE G1776
TYR G1733
TYR G1702
 None
 0.93A 1x70B-2uv8G:
undetectable		 1x70B-2uv8G:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 283
LEU G 246
ALA G 247
VAL G 459
LEU G 267
 None
 1.13A 1xdkA-2uv8G:
undetectable		 1xdkA-2uv8G:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 TYR G1733
LEU G1717
GLN G1775
PHE G1776
ILE G1709
 None
 1.21A 1xosA-2uv8G:
undetectable		 1xosA-2uv8G:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 TYR G1733
LEU G1717
GLN G1775
PHE G1776
ILE G1709
 None
 1.21A 1xotA-2uv8G:
undetectable		 1xotA-2uv8G:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 GLN G 752
PHE G 767
SER G 714
ILE G 717
ASN G 762
 None
 1.49A 2a68M-2uv8G:
0.0		 2a68M-2uv8G:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G 679
GLY G 662
GLY G 623
GLY G 622
ILE G 649
 None
None
None
FMN  G3051 ( 4.5A)
None
 0.89A 2avsA-2uv8G:
undetectable		 2avsA-2uv8G:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 VAL G1015
VAL G1018
ASP G1001
 None
 0.74A 2fumD-2uv8G:
undetectable		 2fumD-2uv8G:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 2fxeB-2uv8G:
undetectable		 2fxeB-2uv8G:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ASN G1696
TYR G1681
SER G1705
 None
 0.87A 2gvcB-2uv8G:
0.0		 2gvcB-2uv8G:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ASN G1696
TYR G1681
SER G1705
 None
 0.82A 2gvcE-2uv8G:
undetectable		 2gvcE-2uv8G:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		6 / 12 LEU G1960
LEU G1904
ILE G1967
SER G1850
PRO G1975
VAL G1842
 None
 1.44A 2hrcA-2uv8G:
undetectable		 2hrcA-2uv8G:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.81A 2hs1B-2uv8G:
undetectable		 2hs1B-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ALA G 280
ALA G 299
ALA G 158
GLY G 161
GLY G 272
 None
 1.08A 2igtB-2uv8G:
undetectable		 2igtB-2uv8G:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 LEU G 781
THR G 777
ILE G1082
HIS G1078
 None
 1.31A 2jfaB-2uv8G:
undetectable		 2jfaB-2uv8G:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 2nmyA-2uv8G:
undetectable		 2nmyA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.93A 2nmyB-2uv8G:
undetectable		 2nmyB-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.87A 2nmzA-2uv8G:
undetectable		 2nmzA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.87A 2nnkA-2uv8G:
undetectable		 2nnkA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 2nnpA-2uv8G:
undetectable		 2nnpA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.89A 2o4sA-2uv8G:
undetectable		 2o4sA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ASP G1344
TYR G1412
LYS G1349
 None
 0.90A 2othA-2uv8G:
undetectable		 2othA-2uv8G:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		6 / 12 GLY G 161
GLY G 531
GLY G 508
GLY G 511
THR G 532
HIS G 102
 None
 1.46A 2oxtB-2uv8G:
undetectable		 2oxtB-2uv8G:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G1958
SER G1850
PRO G1975
VAL G1842
VAL G1886
 None
 1.35A 2pnjB-2uv8G:
undetectable		 2pnjB-2uv8G:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 LEU G1960
LEU G1904
SER G1850
PRO G1975
VAL G1842
 None
 1.36A 2po5B-2uv8G:
undetectable		 2po5B-2uv8G:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.95A 2pymB-2uv8G:
undetectable		 2pymB-2uv8G:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ASP G1646
ASN G1644
THR G1580
 None
 0.72A 2q63B-2uv8G:
undetectable		 2q63B-2uv8G:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASP G 503
VAL G 529
PRO G 506
THR G 166
 None
 1.14A 2q6oB-2uv8G:
undetectable		 2q6oB-2uv8G:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 LEU G 402
ARG G 412
ALA G 398
ILE G 407
 None
 1.17A 2qhfA-2uv8G:
undetectable		 2qhfA-2uv8G:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 THR G 279
ALA G 282
GLU G 285
ILE G 439
LEU G 303
 None
 1.08A 2qxsA-2uv8G:
undetectable		 2qxsA-2uv8G:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 2r5pD-2uv8G:
undetectable		 2r5pD-2uv8G:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 8 ARG G 264
ILE G 283
GLY G 276
PHE G 160
 None
 0.76A 2tsrB-2uv8G:
undetectable		 2tsrB-2uv8G:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 GLY G 272
ASP G 467
LEU G 468
ARG G 469
 None
 0.67A 2uyqA-2uv8G:
undetectable		 2uyqA-2uv8G:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 PHE G1242
ILE G1219
ILE G1170
GLY G1247
 None
 0.93A 2v0mB-2uv8G:
undetectable		 2v0mB-2uv8G:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 8 THR G1301
VAL G1304
GLU G1594
ALA G1591
PRO G1322
 None
 1.32A 2v32A-2uv8G:
undetectable
2v32B-2uv8G:
undetectable		 2v32A-2uv8G:
7.53
2v32B-2uv8G:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 8 PRO G1322
THR G1301
VAL G1304
GLU G1594
ALA G1591
 None
 1.32A 2v32A-2uv8G:
undetectable
2v32B-2uv8G:
undetectable		 2v32A-2uv8G:
7.53
2v32B-2uv8G:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 9 THR G1301
VAL G1304
GLU G1594
ALA G1591
PRO G1322
 None
 1.32A 2v41A-2uv8G:
undetectable
2v41B-2uv8G:
undetectable		 2v41A-2uv8G:
7.53
2v41B-2uv8G:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_B_BEZB1222_0
(PEROXIREDOXIN 6.)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 9 PRO G1322
THR G1301
VAL G1304
GLU G1594
ALA G1591
 None
 1.36A 2v41A-2uv8G:
undetectable
2v41B-2uv8G:
undetectable		 2v41A-2uv8G:
7.53
2v41B-2uv8G:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 10 THR G1777
SER G1973
SER G1850
GLY G1835
GLN G1669
 None
 1.36A 2x2iB-2uv8G:
undetectable		 2x2iB-2uv8G:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ARG G 264
ILE G 455
ILE G 483
LEU G 443
 None
 0.96A 2xkwB-2uv8G:
undetectable		 2xkwB-2uv8G:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G1396
VAL G1372
VAL G1605
PHE G1311
ASN G1306
 None
 1.18A 2y00A-2uv8G:
undetectable		 2y00A-2uv8G:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G1396
VAL G1372
VAL G1605
PHE G1311
ASN G1306
 None
 1.19A 2y01B-2uv8G:
undetectable		 2y01B-2uv8G:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G1960
LEU G1904
ILE G1967
SER G1850
VAL G1842
 None
 1.07A 3aqiB-2uv8G:
undetectable		 3aqiB-2uv8G:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 ILE G 843
HIS G1055
ARG G 736
GLY G 738
 None
None
None
FMN  G3051 (-3.6A)
 1.31A 3b9mA-2uv8G:
undetectable		 3b9mA-2uv8G:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 GLY G1247
GLY G1104
GLY G1105
GLY G 588
 None
 0.67A 3bogC-2uv8G:
undetectable		 3bogC-2uv8G:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 SER G 803
GLY G 802
GLY G1056
GLY G 739
 FMN  G3051 (-2.8A)
FMN  G3051 (-3.5A)
FMN  G3051 ( 4.1A)
FMN  G3051 ( 4.3A)
 0.92A 3bogB-2uv8G:
undetectable
3bogD-2uv8G:
undetectable		 3bogB-2uv8G:
undetectable
3bogD-2uv8G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.82A 3bvbA-2uv8G:
undetectable		 3bvbA-2uv8G:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 3d1xB-2uv8G:
undetectable		 3d1xB-2uv8G:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.89A 3d1yA-2uv8G:
undetectable		 3d1yA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.84A 3d1zA-2uv8G:
undetectable		 3d1zA-2uv8G:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.97A 3dd1A-2uv8G:
2.0		 3dd1A-2uv8G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.96A 3dd1B-2uv8G:
undetectable		 3dd1B-2uv8G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.98A 3ddsA-2uv8G:
undetectable		 3ddsA-2uv8G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.97A 3ddsB-2uv8G:
undetectable		 3ddsB-2uv8G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.95A 3ddwA-2uv8G:
undetectable		 3ddwA-2uv8G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ASN G 153
HIS G 500
ALA G 148
GLY G 150
 None
 0.95A 3ddwB-2uv8G:
undetectable		 3ddwB-2uv8G:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ILE G 483
SER G 274
LEU G 277
THR G 462
 None
 0.94A 3deuB-2uv8G:
undetectable		 3deuB-2uv8G:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 ILE G 728
GLN G 731
ILE G 717
LEU G 593
 None
 1.35A 3dzyD-2uv8G:
0.0		 3dzyD-2uv8G:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 8 GLY G 531
ALA G 530
ASP G 503
ILE G 547
 None
 0.67A 3el0A-2uv8G:
undetectable		 3el0A-2uv8G:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 3el4A-2uv8G:
undetectable		 3el4A-2uv8G:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 10 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.91A 3el9B-2uv8G:
undetectable		 3el9B-2uv8G:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 PHE G 583
ILE G 766
THR G 680
VAL G 607
ILE G 617
 None
 1.25A 3em0B-2uv8G:
undetectable		 3em0B-2uv8G:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ASP G1791
LEU G1792
GLN G1659
 None
 0.82A 3g4lA-2uv8G:
undetectable		 3g4lA-2uv8G:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 841
GLY G 842
ALA G 858
ALA G1060
PRO G 828
 None
 1.02A 3jayA-2uv8G:
undetectable		 3jayA-2uv8G:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LYS G 866
GLY G 841
GLY G 842
ALA G 858
ALA G1060
 None
 1.09A 3jayA-2uv8G:
undetectable		 3jayA-2uv8G:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 8 TYR G 780
GLU G 784
PHE G 771
ILE G1077
 None
 1.01A 3jz0B-2uv8G:
1.1		 3jz0B-2uv8G:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.93A 3k4vD-2uv8G:
undetectable		 3k4vD-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 GLN G 163
PHE G 427
TYR G 311
LEU G 339
 None
 1.38A 3keeC-2uv8G:
0.0		 3keeC-2uv8G:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.87A 3ndtB-2uv8G:
undetectable		 3ndtB-2uv8G:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.93A 3nduB-2uv8G:
undetectable		 3nduB-2uv8G:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.94A 3nduD-2uv8G:
undetectable		 3nduD-2uv8G:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 1.00A 3ndxA-2uv8G:
undetectable		 3ndxA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.90A 3ndxB-2uv8G:
undetectable		 3ndxB-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.90A 3nu3A-2uv8G:
undetectable		 3nu3A-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.96A 3oxcA-2uv8G:
undetectable		 3oxcA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 1.01A 3oxcB-2uv8G:
undetectable		 3oxcB-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 9 LYS G1358
THR G1407
SER G1397
THR G1395
VAL G1393
 None
 1.14A 3ozkA-2uv8G:
undetectable		 3ozkA-2uv8G:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 3pwrA-2uv8G:
undetectable		 3pwrA-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.88A 3pwrB-2uv8G:
undetectable		 3pwrB-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 8 ALA G 923
ILE G 980
LEU G 951
ALA G 990
 None
 0.64A 3r9tA-2uv8G:
undetectable		 3r9tA-2uv8G:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 ILE G 244
LEU G 173
HIS G 248
VAL G 117
 None
 0.96A 3r9vA-2uv8G:
undetectable
3r9vB-2uv8G:
undetectable		 3r9vA-2uv8G:
9.22
3r9vB-2uv8G:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 PHE G1976
SER G1808
GLN G1669
 None
 0.88A 3smtA-2uv8G:
undetectable		 3smtA-2uv8G:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G1653
GLY G1607
ALA G1655
ALA G1598
SER G1600
 None
 1.10A 3sudA-2uv8G:
undetectable		 3sudA-2uv8G:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 GLN G 163
PHE G 427
TYR G 311
LEU G 339
 None
 1.38A 3sugA-2uv8G:
0.0		 3sugA-2uv8G:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 LEU G 800
GLY G 772
ALA G1059
PHE G1062
 None
None
FMN  G3051 (-3.5A)
None
 0.99A 3tehB-2uv8G:
undetectable		 3tehB-2uv8G:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 GLN G1088
TYR G1089
PRO G 567
LEU G 562
 None
 0.88A 3tgvD-2uv8G:
undetectable		 3tgvD-2uv8G:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.91A 3tkgA-2uv8G:
undetectable		 3tkgA-2uv8G:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.98A 3tkgB-2uv8G:
undetectable		 3tkgB-2uv8G:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.90A 3tkgD-2uv8G:
undetectable		 3tkgD-2uv8G:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 101
LEU G 255
ALA G 129
LEU G 183
GLY G  62
 None
 0.94A 3uq6B-2uv8G:
undetectable		 3uq6B-2uv8G:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ILE G 101
LEU G 255
ALA G 129
LEU G 183
GLY G  62
 None
 0.97A 3vaqB-2uv8G:
undetectable		 3vaqB-2uv8G:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 PHE G1103
ASN G1246
GLY G1104
GLY G 575
GLU G1094
 None
 1.44A 4a6nB-2uv8G:
0.0		 4a6nB-2uv8G:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 PHE G1300
ASP G1559
ILE G1563
GLY G1582
SER G1586
 None
 1.42A 4djfB-2uv8G:
undetectable		 4djfB-2uv8G:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 10 VAL G 243
ALA G 299
SER G 237
LEU G 213
THR G 279
 None
 1.49A 4eilB-2uv8G:
undetectable		 4eilB-2uv8G:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 10 VAL G 243
ALA G 299
SER G 237
LEU G 213
THR G 279
 None
 1.48A 4eilG-2uv8G:
undetectable		 4eilG-2uv8G:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 PHE G 771
VAL G1058
PHE G 767
GLY G 734
 None
 0.96A 4ejjB-2uv8G:
undetectable		 4ejjB-2uv8G:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 8 ILE G1053
LYS G1064
ILE G 807
GLY G 826
 None
 0.86A 4hb6A-2uv8G:
undetectable		 4hb6A-2uv8G:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.89A 4jecB-2uv8G:
undetectable		 4jecB-2uv8G:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 TYR G 780
THR G 777
ARG G 736
PHE G1062
 None
 1.36A 4kf9A-2uv8G:
undetectable		 4kf9A-2uv8G:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 PHE G 548
ALA G 103
LEU G 256
GLY G 542
LEU G 502
 None
 1.25A 4kykA-2uv8G:
undetectable
4kykB-2uv8G:
undetectable		 4kykA-2uv8G:
6.51
4kykB-2uv8G:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 THR G 286
THR G 252
LEU G 156
LEU G 267
 None
 1.05A 4lvcB-2uv8G:
undetectable		 4lvcB-2uv8G:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.94A 4njvD-2uv8G:
undetectable		 4njvD-2uv8G:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ILE G 681
GLY G 684
ILE G 713
LEU G 703
 None
 0.63A 4o8fB-2uv8G:
undetectable		 4o8fB-2uv8G:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 MET G 658
MET G1011
TYR G 624
 None
 1.20A 4p6xI-2uv8G:
undetectable		 4p6xI-2uv8G:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.93A 4qgiA-2uv8G:
undetectable		 4qgiA-2uv8G:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 ALA G 905
THR G 906
ALA G 911
THR G 916
 None
 0.94A 4qw0K-2uv8G:
undetectable		 4qw0K-2uv8G:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 ALA G 905
THR G 906
ALA G 911
THR G 916
 None
 0.93A 4qw0Y-2uv8G:
undetectable		 4qw0Y-2uv8G:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 VAL G 488
TRP G 490
THR G 279
GLN G 245
ILE G 306
 None
 0.87A 4s0vA-2uv8G:
undetectable		 4s0vA-2uv8G:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 SER G 274
GLY G 161
GLY G 162
ASN G 165
GLN G 163
 None
 1.25A 4ubeA-2uv8G:
undetectable		 4ubeA-2uv8G:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 PHE G 292
SER G 295
VAL G 250
PHE G 504
 None
 1.05A 4wnvD-2uv8G:
0.0		 4wnvD-2uv8G:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 LEU G 219
LEU G 216
GLU G 217
ASN G 214
 None
 0.94A 4ww7A-2uv8G:
undetectable		 4ww7A-2uv8G:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 ASN G 612
SER G 639
ALA G 608
VAL G 607
 None
 1.33A 4x1kC-2uv8G:
0.0		 4x1kC-2uv8G:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 TYR G1572
TYR G1266
GLU G1253
ASP G1162
 None
 1.34A 4x61A-2uv8G:
2.1		 4x61A-2uv8G:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 LYS G 134
ARG G 135
LEU G  84
ASP G  81
 None
 1.37A 4xdtA-2uv8G:
undetectable		 4xdtA-2uv8G:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ILE G 101
VAL G 251
PHE G 137
ARG G 135
 None
 1.16A 4xe5A-2uv8G:
undetectable		 4xe5A-2uv8G:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ALA G 192
GLU G 193
LEU G 195
LEU G 173
PRO G 239
 None
 1.27A 4xi3A-2uv8G:
undetectable		 4xi3A-2uv8G:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ALA G 192
GLU G 193
LEU G 195
LEU G 173
PRO G 239
 None
 1.30A 4xi3D-2uv8G:
undetectable		 4xi3D-2uv8G:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ALA G 509
SER G 510
ASP G 538
PRO G 537
 None
 1.05A 5c6pA-2uv8G:
undetectable		 5c6pA-2uv8G:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 PHE G1764
SER G1761
HIS G1720
LEU G1717
 None
 1.21A 5dzke-2uv8G:
0.7
5dzks-2uv8G:
undetectable		 5dzke-2uv8G:
7.39
5dzks-2uv8G:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ASN G1383
ASP G1344
GLY G1345
 None
 0.66A 5fctB-2uv8G:
undetectable		 5fctB-2uv8G:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 VAL G2003
ALA G2007
GLN G2020
VAL G2021
 None
 0.67A 5i8fA-2uv8G:
undetectable		 5i8fA-2uv8G:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 9 ILE G 241
PRO G 506
VAL G 488
LEU G 370
LEU G 232
 None
 1.41A 5iepA-2uv8G:
undetectable		 5iepA-2uv8G:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 9 ILE G1563
HIS G1564
ARG G1413
PHE G1410
VAL G1392
 None
 1.17A 5igzA-2uv8G:
undetectable		 5igzA-2uv8G:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.83A 5kqxA-2uv8G:
undetectable		 5kqxA-2uv8G:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 LEU G 339
LEU G 386
SER G 385
THR G 356
 None
 1.14A 5l4iB-2uv8G:
undetectable		 5l4iB-2uv8G:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 THR G 646
THR G 616
THR G 611
THR G 610
GLY G 648
 None
 1.46A 5l66V-2uv8G:
undetectable
5l66b-2uv8G:
undetectable		 5l66V-2uv8G:
7.95
5l66b-2uv8G:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 11 THR G 646
THR G 616
THR G 611
THR G 610
GLY G 648
 None
 1.46A 5l66H-2uv8G:
undetectable
5l66N-2uv8G:
undetectable		 5l66H-2uv8G:
7.95
5l66N-2uv8G:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 10 GLU G 121
PHE G  37
THR G  10
PRO G  54
LEU G  60
 None
 1.34A 5mm4B-2uv8G:
undetectable		 5mm4B-2uv8G:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 9 SER G1585
THR G1546
THR G1620
ILE G1579
THR G1642
 None
 1.43A 5muoA-2uv8G:
0.1
5muoB-2uv8G:
0.1
5muoC-2uv8G:
0.1
5muoD-2uv8G:
0.0
5muoE-2uv8G:
0.1		 5muoA-2uv8G:
3.30
5muoB-2uv8G:
3.30
5muoC-2uv8G:
3.30
5muoD-2uv8G:
3.30
5muoE-2uv8G:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 4 ASN G 612
SER G 639
ALA G 608
VAL G 607
 None
 1.27A 5nm5A-2uv8G:
undetectable		 5nm5A-2uv8G:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 THR G1063
HIS G1055
MET G 597
THR G 813
 None
None
FMN  G3051 (-4.4A)
None
 1.13A 5u6mA-2uv8G:
0.1		 5u6mA-2uv8G:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 THR G1063
HIS G1055
MET G 597
THR G 813
 None
None
FMN  G3051 (-4.4A)
None
 1.13A 5u6mB-2uv8G:
undetectable		 5u6mB-2uv8G:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 6 ARG G1555
PHE G1300
ILE G1292
THR G1293
 None
 0.96A 5vceA-2uv8G:
undetectable		 5vceA-2uv8G:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 ILE G1170
ALA G1152
PHE G1154
THR G1193
ILE G1184
 None
 1.33A 5z6fA-2uv8G:
undetectable		 5z6fA-2uv8G:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 511
GLY G 513
ILE G 244
GLY G 508
GLY G 507
 None
 0.77A 5zhmB-2uv8G:
undetectable		 5zhmB-2uv8G:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 HIS G1977
GLY G1806
GLY G1810
ALA G1813
ILE G2011
 None
 1.09A 6b3aA-2uv8G:
undetectable		 6b3aA-2uv8G:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 HIS G1977
GLY G1806
GLY G1810
ALA G1813
ILE G2011
 None
 1.14A 6b3bA-2uv8G:
undetectable		 6b3bA-2uv8G:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 ILE G 188
PHE G 292
ILE G 236
ALA G 299
 None
 0.87A 6b5vA-2uv8G:
0.0
6b5vC-2uv8G:
undetectable		 6b5vA-2uv8G:
3.87
6b5vC-2uv8G:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 ALA G 299
ILE G 188
PHE G 292
ILE G 236
 None
 0.88A 6b5vA-2uv8G:
0.0
6b5vB-2uv8G:
undetectable		 6b5vA-2uv8G:
3.87
6b5vB-2uv8G:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 7 ILE G 188
PHE G 292
ILE G 236
ALA G 299
 None
 0.87A 6b5vC-2uv8G:
undetectable
6b5vD-2uv8G:
0.0		 6b5vC-2uv8G:
3.87
6b5vD-2uv8G:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 TYR G 890
ALA G 897
LEU G 864
 None
 0.66A 6d9kF-2uv8G:
undetectable		 6d9kF-2uv8G:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 GLY G 621
ALA G 620
ILE G 617
GLY G 648
ILE G 676
 None
FMN  G3051 ( 4.7A)
None
None
None
 0.86A 6dh3B-2uv8G:
undetectable		 6dh3B-2uv8G:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		5 / 12 LEU G1040
ILE G1053
HIS G1055
THR G1063
THR G 859
 None
 1.23A 6djzB-2uv8G:
undetectable		 6djzB-2uv8G:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ALA G 424
PHE G 427
GLN G 275
 None
 0.69A 6eceA-2uv8G:
0.2		 6eceA-2uv8G:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 LEU G 471
THR G 462
PRO G 458
ARG G 264
 None
 1.33A 6ew0B-2uv8G:
undetectable		 6ew0B-2uv8G:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 LEU G 471
THR G 462
PRO G 458
ARG G 264
 None
 1.33A 6ew0D-2uv8G:
undetectable		 6ew0D-2uv8G:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 LEU G 471
THR G 462
PRO G 458
ARG G 264
 None
 1.33A 6ew0H-2uv8G:
undetectable		 6ew0H-2uv8G:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		4 / 5 LEU G 471
THR G 462
PRO G 458
ARG G 264
 None
 1.33A 6ew0I-2uv8G:
undetectable		 6ew0I-2uv8G:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 LEU G1809
GLY G1835
PHE G1698
 None
 0.64A 6exiC-2uv8G:
undetectable		 6exiC-2uv8G:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)
(Saccharomyces
cerevisiae) 		3 / 3 ARG G 419
GLY G 333
GLU G 332
 None
 0.58A 6fgdA-2uv8G:
undetectable		 6fgdA-2uv8G:
12.25