SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 10 LEU A 171
SER A 220
LEU A 201
ALA A 200
PHE A 162
None
1.19A 1g5yC-2uvfA:
undetectable
1g5yC-2uvfA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 11 GLY A 219
GLY A 271
ILE A 216
TYR A 196
PRO A 192
None
1.17A 1p91A-2uvfA:
undetectable
1p91A-2uvfA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.87A 1v55N-2uvfA:
undetectable
1v55W-2uvfA:
undetectable
1v55N-2uvfA:
22.56
1v55W-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 TYR A 510
GLY A 412
GLY A 475
THR A 444
ILE A 508
None
1.03A 2azxA-2uvfA:
undetectable
2azxA-2uvfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 THR A 411
GLY A 410
GLY A 386
GLU A 361
GLN A 418
None
1.26A 2azxB-2uvfA:
undetectable
2azxB-2uvfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.85A 2eijN-2uvfA:
undetectable
2eijW-2uvfA:
undetectable
2eijN-2uvfA:
22.56
2eijW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.89A 2eikA-2uvfA:
undetectable
2eikJ-2uvfA:
undetectable
2eikA-2uvfA:
22.56
2eikJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.85A 2eikN-2uvfA:
undetectable
2eikW-2uvfA:
undetectable
2eikN-2uvfA:
22.56
2eikW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.85A 2eilN-2uvfA:
undetectable
2eilW-2uvfA:
undetectable
2eilN-2uvfA:
22.56
2eilW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 TYR A 375
MET A 433
THR A 461
LEU A 460
None
1.45A 2eimJ-2uvfA:
undetectable
2eimJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.79A 2einA-2uvfA:
undetectable
2einJ-2uvfA:
undetectable
2einA-2uvfA:
22.56
2einJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 GLU A  61
LYS A  58
ASN A 455
ALA A  59
None
1.43A 2ejgB-2uvfA:
undetectable
2ejgB-2uvfA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 LEU A 333
ALA A 377
ASN A 378
GLY A 305
ILE A 306
None
None
SO4  A1612 (-3.2A)
None
None
0.93A 2f80B-2uvfA:
undetectable
2f80B-2uvfA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 ALA A 513
GLY A 410
SER A 469
None
0.57A 2ivuA-2uvfA:
undetectable
2ivuA-2uvfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 TYR A 233
GLU A 361
THR A 335
None
0.62A 2y7hB-2uvfA:
undetectable
2y7hB-2uvfA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 ILE A 191
LEU A 211
LEU A 203
ILE A 180
ALA A 179
None
1.08A 3a50D-2uvfA:
undetectable
3a50D-2uvfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.86A 3abkA-2uvfA:
undetectable
3abkJ-2uvfA:
undetectable
3abkA-2uvfA:
22.56
3abkJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.91A 3ablN-2uvfA:
undetectable
3ablW-2uvfA:
undetectable
3ablN-2uvfA:
22.56
3ablW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.88A 3abmN-2uvfA:
undetectable
3abmW-2uvfA:
undetectable
3abmN-2uvfA:
22.56
3abmW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 TYR A 375
MET A 433
THR A 461
LEU A 460
None
1.44A 3ag2J-2uvfA:
undetectable
3ag2J-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.86A 3ag3N-2uvfA:
0.0
3ag3W-2uvfA:
undetectable
3ag3N-2uvfA:
22.56
3ag3W-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 TYR A 375
MET A 433
THR A 461
LEU A 460
None
1.43A 3ag4J-2uvfA:
undetectable
3ag4J-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.90A 3asnN-2uvfA:
undetectable
3asnW-2uvfA:
undetectable
3asnN-2uvfA:
22.56
3asnW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.89A 3asoN-2uvfA:
undetectable
3asoW-2uvfA:
undetectable
3asoN-2uvfA:
22.56
3asoW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 PRO A  90
PRO A  93
TYR A  94
TYR A 430
SO4  A1611 (-3.6A)
None
SO4  A1610 (-3.9A)
None
1.02A 3d9lA-2uvfA:
undetectable
3d9lY-2uvfA:
undetectable
3d9lA-2uvfA:
13.32
3d9lY-2uvfA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 SER A 388
ILE A 383
ASN A 362
VAL A 365
None
0.70A 3dcjB-2uvfA:
undetectable
3dcjB-2uvfA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 THR A 173
ILE A 180
ASP A 181
GLN A 178
ALA A 179
None
1.11A 3ddyA-2uvfA:
undetectable
3ddyA-2uvfA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 ILE A 448
PHE A 519
HIS A 443
None
None
AD0  A1617 (-3.8A)
0.70A 3h0aA-2uvfA:
undetectable
3h0aA-2uvfA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 10 LEU A 333
ALA A 377
ASN A 378
GLY A 305
ILE A 306
None
None
SO4  A1612 (-3.2A)
None
None
0.92A 3lzvA-2uvfA:
undetectable
3lzvA-2uvfA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 9 GLY A 346
ASN A 368
PRO A  90
SER A  89
HIS A 372
None
None
SO4  A1611 (-3.6A)
None
None
1.45A 3ndiA-2uvfA:
0.4
3ndiA-2uvfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 4 SER A 236
GLY A 386
GLU A 449
None
0.67A 3raeA-2uvfA:
undetectable
3raeC-2uvfA:
undetectable
3raeA-2uvfA:
21.73
3raeC-2uvfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 LEU A 333
ALA A 377
GLY A 305
ILE A 306
None
0.74A 3spkB-2uvfA:
undetectable
3spkB-2uvfA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
6 / 12 GLN A 418
TYR A 510
GLY A 410
GLY A 386
ALA A 408
SER A 332
None
None
None
None
AD0  A1617 ( 3.8A)
None
1.42A 3sudB-2uvfA:
undetectable
3sudB-2uvfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 9 PHE A 431
PHE A 407
ASN A 456
ILE A 438
PHE A 385
None
1.44A 3t3rC-2uvfA:
undetectable
3t3rC-2uvfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 LEU A 460
GLY A 287
LEU A 286
GLU A 285
ASP A 399
None
1.27A 3tbgA-2uvfA:
undetectable
3tbgA-2uvfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 LEU A 460
GLY A 287
LEU A 286
GLU A 285
ASP A 399
None
1.27A 3tbgC-2uvfA:
undetectable
3tbgC-2uvfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 HIS A 443
LEU A 232
GLY A 412
ALA A 415
AD0  A1617 (-3.8A)
AD0  A1617 (-4.7A)
None
None
0.94A 3tehB-2uvfA:
undetectable
3tehB-2uvfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 LEU A 333
GLY A 356
PHE A 347
ASN A 359
None
1.05A 3uq6B-2uvfA:
undetectable
3uq6B-2uvfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 GLY A 464
ASP A 462
GLY A 436
CYH A 404
None
0.58A 4c5nA-2uvfA:
undetectable
4c5nA-2uvfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 GLY A 464
ASP A 462
GLY A 436
CYH A 404
None
0.59A 4c5nC-2uvfA:
undetectable
4c5nC-2uvfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 6 GLU A 285
LEU A 460
MET A 433
ASP A 399
None
1.49A 4cevA-2uvfA:
undetectable
4cevB-2uvfA:
undetectable
4cevA-2uvfA:
18.95
4cevB-2uvfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ASN A 362
GLY A 338
VAL A 339
ILE A 248
None
0.86A 4fglC-2uvfA:
undetectable
4fglC-2uvfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 6 LEU A 201
ASN A 246
LEU A 209
VAL A 342
None
1.17A 4okbA-2uvfA:
undetectable
4okbA-2uvfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 GLY A 401
TYR A 459
GLY A 287
THR A 283
THR A 374
NI  A1614 (-3.7A)
None
None
None
None
1.18A 4zdyA-2uvfA:
undetectable
4zdyA-2uvfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 11 TYR A 235
SER A 236
GLU A 419
THR A 411
GLY A 410
None
1.35A 4zjoD-2uvfA:
undetectable
4zjoD-2uvfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ARG A 276
PHE A 397
ARG A 432
ASP A 399
NI  A1615 (-4.5A)
SO4  A1610 (-2.9A)
None
None
1.46A 5a06F-2uvfA:
undetectable
5a06F-2uvfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.91A 5b1bN-2uvfA:
undetectable
5b1bW-2uvfA:
undetectable
5b1bN-2uvfA:
22.56
5b1bW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.92A 5b3sN-2uvfA:
undetectable
5b3sW-2uvfA:
undetectable
5b3sN-2uvfA:
22.56
5b3sW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ASP A 399
ARG A 432
GLU A 285
ARG A 350
None
0.98A 5bs8A-2uvfA:
undetectable
5bs8B-2uvfA:
undetectable
5bs8C-2uvfA:
undetectable
5bs8A-2uvfA:
22.71
5bs8B-2uvfA:
18.70
5bs8C-2uvfA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ASP A 399
ARG A 432
GLU A 285
ARG A 350
None
0.97A 5btdA-2uvfA:
undetectable
5btdB-2uvfA:
undetectable
5btdC-2uvfA:
undetectable
5btdA-2uvfA:
22.71
5btdB-2uvfA:
18.70
5btdC-2uvfA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ARG A 350
ASP A 399
ARG A 432
GLU A 285
None
0.97A 5btdA-2uvfA:
undetectable
5btdC-2uvfA:
undetectable
5btdD-2uvfA:
undetectable
5btdA-2uvfA:
22.71
5btdC-2uvfA:
22.71
5btdD-2uvfA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ASP A 399
ARG A 432
GLU A 285
ARG A 350
None
0.99A 5btfA-2uvfA:
undetectable
5btfB-2uvfA:
undetectable
5btfC-2uvfA:
undetectable
5btfA-2uvfA:
22.86
5btfB-2uvfA:
18.70
5btfC-2uvfA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 ARG A 350
ASP A 399
ARG A 432
GLU A 285
None
1.00A 5btfA-2uvfA:
undetectable
5btfC-2uvfA:
undetectable
5btfD-2uvfA:
undetectable
5btfA-2uvfA:
22.86
5btfC-2uvfA:
22.86
5btfD-2uvfA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 GLY A 346
ILE A 165
GLY A 163
LEU A 217
THR A 264
None
0.94A 5eqbA-2uvfA:
undetectable
5eqbA-2uvfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 GLY A 401
TYR A 459
GLY A 287
THR A 283
THR A 374
NI  A1614 (-3.7A)
None
None
None
None
1.19A 5eslA-2uvfA:
undetectable
5eslA-2uvfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 6 PHE A 482
PHE A 577
THR A 567
TRP A 591
None
1.21A 5g08A-2uvfA:
undetectable
5g08A-2uvfA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 PHE A 385
ILE A 405
GLY A 441
PHE A 407
None
None
AD0  A1617 (-4.6A)
None
0.77A 5h3aA-2uvfA:
undetectable
5h3aA-2uvfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 ARG A 330
GLY A 441
SER A 442
GLY A 380
HIS A 435
None
AD0  A1617 (-4.6A)
AD0  A1617 (-3.4A)
None
NI  A1614 ( 3.4A)
0.97A 5hikA-2uvfA:
undetectable
5hikA-2uvfA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 LEU A 201
LEU A 217
ARG A 330
None
0.59A 5hnzB-2uvfA:
undetectable
5hnzB-2uvfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 7 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.87A 5iy5N-2uvfA:
undetectable
5iy5W-2uvfA:
undetectable
5iy5N-2uvfA:
22.56
5iy5W-2uvfA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 TYR A 230
GLY A 229
GLY A 265
LEU A 333
None
0.86A 5jlcA-2uvfA:
undetectable
5jlcA-2uvfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 VAL A 130
TYR A  69
GLN A  70
None
0.68A 5qgkA-2uvfA:
undetectable
5qgkA-2uvfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 VAL A 130
TYR A  69
GLN A  70
None
0.65A 5qgrA-2uvfA:
undetectable
5qgrA-2uvfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 VAL A 130
TYR A  69
GLN A  70
None
0.67A 5qgtA-2uvfA:
undetectable
5qgtA-2uvfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 LEU A 465
ALA A 453
ILE A 405
GLY A 423
ILE A 438
None
0.90A 5t8hB-2uvfA:
undetectable
5t8hB-2uvfA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
3 / 3 HIS A 555
SER A 575
ARG A 552
None
0.94A 5u63A-2uvfA:
undetectable
5u63A-2uvfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 ARG A 350
LEU A 171
ILE A 176
ALA A 164
ALA A 193
None
1.16A 5vc0A-2uvfA:
undetectable
5vc0A-2uvfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 HIS A 372
MET A 334
ASN A 406
LEU A 333
None
None
AD0  A1617 (-3.0A)
None
1.38A 5xdhB-2uvfA:
0.0
5xdhB-2uvfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 6 HIS A 372
MET A 334
ASN A 406
LEU A 333
None
None
AD0  A1617 (-3.0A)
None
1.33A 5xdhA-2uvfA:
undetectable
5xdhC-2uvfA:
undetectable
5xdhA-2uvfA:
9.52
5xdhC-2uvfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 5 HIS A 372
MET A 334
ASN A 406
LEU A 333
None
None
AD0  A1617 (-3.0A)
None
1.46A 5xdhD-2uvfA:
undetectable
5xdhD-2uvfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.93A 5xdxN-2uvfA:
undetectable
5xdxW-2uvfA:
undetectable
5xdxN-2uvfA:
22.56
5xdxW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 GLY A 380
GLY A 434
ASN A 351
ASP A 402
PHE A 354
None
None
None
AD0  A1617 (-3.1A)
AD0  A1617 ( 4.9A)
1.32A 5yn6A-2uvfA:
undetectable
5yn6A-2uvfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.90A 5zcoA-2uvfA:
undetectable
5zcoJ-2uvfA:
undetectable
5zcoA-2uvfA:
22.56
5zcoJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.89A 5zcpN-2uvfA:
undetectable
5zcpW-2uvfA:
undetectable
5zcpN-2uvfA:
22.56
5zcpW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 8 PHE A 347
MET A 334
THR A 335
LEU A 336
None
0.91A 5zcqN-2uvfA:
undetectable
5zcqW-2uvfA:
undetectable
5zcqN-2uvfA:
22.56
5zcqW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 10 VAL A 365
PHE A 385
LEU A 370
ASN A 396
ILE A 357
None
1.43A 6d9hR-2uvfA:
undetectable
6d9hR-2uvfA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
5 / 12 GLY A 401
TYR A 459
GLY A 287
THR A 283
THR A 374
NI  A1614 (-3.7A)
None
None
None
None
1.16A 6e8qA-2uvfA:
undetectable
6e8qA-2uvfA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
2uvf EXOPOLYGALACTURONASE
(Yersinia
enterocolitica)
4 / 6 ILE A 282
ALA A 277
ARG A 276
ASP A 270
None
None
NI  A1615 (-4.5A)
NI  A1615 (-3.9A)
1.14A 6hu9m-2uvfA:
undetectable
6hu9q-2uvfA:
undetectable
6hu9m-2uvfA:
23.78
6hu9q-2uvfA:
12.29