SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		5 / 10 GLY A 344
LEU A 341
SER A 277
ASN A 270
TYR A 146
 None
 1.49A 2h21A-2uvjA:
undetectable		 2h21A-2uvjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		5 / 11 GLY A 344
LEU A 341
SER A 277
ASN A 270
TYR A 146
 None
 1.47A 2h21B-2uvjA:
undetectable		 2h21B-2uvjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		5 / 11 GLY A 344
LEU A 341
SER A 277
ASN A 270
TYR A 146
 None
 1.43A 2h21C-2uvjA:
undetectable		 2h21C-2uvjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 7 ARG A 143
THR A 141
ASN A  92
GLN A 189
 ADA  A1431 ( 2.8A)
ADA  A1433 ( 4.5A)
None
ADA  A1432 ( 2.8A)
 1.11A 2jc9A-2uvjA:
undetectable		 2jc9A-2uvjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 7 ARG A 143
THR A 272
ASN A  90
GLN A 189
 ADA  A1431 ( 2.8A)
ADA  A1433 (-3.4A)
ADA  A1433 (-3.0A)
ADA  A1432 ( 2.8A)
 1.01A 2jc9A-2uvjA:
undetectable		 2jc9A-2uvjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		5 / 11 VAL A 336
LEU A 341
VAL A 345
ILE A 361
ALA A 349
 None
 1.18A 2zbzA-2uvjA:
undetectable		 2zbzA-2uvjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		3 / 3 TYR A 229
GLU A 187
ASP A  68
 None
ADA  A1431 (-3.2A)
None
 0.65A 3bxoA-2uvjA:
undetectable		 3bxoA-2uvjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		3 / 3 TYR A 229
GLU A 187
ASP A  68
 None
ADA  A1431 (-3.2A)
None
 0.66A 3bxoB-2uvjA:
undetectable		 3bxoB-2uvjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 4 GLY A 170
VAL A 237
GLY A 265
THR A 266
 None
 0.93A 3ib2A-2uvjA:
4.9		 3ib2A-2uvjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 5 PRO A 206
ILE A 205
TYR A 386
TRP A  91
 None
 1.29A 3phaA-2uvjA:
0.0		 3phaA-2uvjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 6 ILE A 138
ILE A  78
MET A  87
TRP A  93
 None
 1.44A 3weoA-2uvjA:
undetectable		 3weoA-2uvjA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		3 / 3 ASN A  90
ASP A 388
ASP A 190
 ADA  A1433 (-3.0A)
ADA  A1432 ( 4.7A)
ADA  A1431 (-3.0A)
 0.75A 4obwD-2uvjA:
undetectable		 4obwD-2uvjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 8 ILE A 195
PHE A 396
THR A 207
PHE A 387
 None
 0.84A 5x23A-2uvjA:
undetectable		 5x23A-2uvjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2uvj ABC TYPE PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Yersinia
enterocolitica) 		4 / 6 ALA A 284
GLY A 265
THR A 266
ILE A 273
 None
 0.81A 6f8cA-2uvjA:
0.6		 6f8cA-2uvjA:
12.06