SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2uvk YJHT
(Escherichia
coli) 		4 / 8 GLY A 126
THR A 124
GLY A 190
LEU A 205
 None
 0.74A 1aegA-2uvkA:
undetectable		 1aegA-2uvkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2uvk YJHT
(Escherichia
coli) 		5 / 12 ILE A 206
GLY A 245
ALA A 261
VAL A 113
ALA A 192
 None
 1.22A 1vq1A-2uvkA:
undetectable		 1vq1A-2uvkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2uvk YJHT
(Escherichia
coli) 		4 / 8 GLY A 329
GLU A 325
ALA A 327
GLN A 305
 None
 0.85A 2dtjA-2uvkA:
undetectable
2dtjB-2uvkA:
undetectable		 2dtjA-2uvkA:
20.39
2dtjB-2uvkA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uvk YJHT
(Escherichia
coli) 		4 / 6 SER A 266
ARG A 215
PRO A 212
GLY A 213
 None
 1.35A 2y7pA-2uvkA:
undetectable		 2y7pA-2uvkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2uvk YJHT
(Escherichia
coli) 		3 / 3 TRP A  98
VAL A 311
ARG A 307
 None
 0.84A 3b0wA-2uvkA:
undetectable		 3b0wA-2uvkA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2uvk YJHT
(Escherichia
coli) 		5 / 12 ILE A 250
GLY A 249
ALA A 258
PRO A 314
VAL A 197
 None
 0.98A 3jb3A-2uvkA:
undetectable		 3jb3A-2uvkA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2uvk YJHT
(Escherichia
coli) 		5 / 9 VAL A  22
ILE A  24
GLY A  13
SER A  28
ALA A  29
 None
 1.10A 4fwdA-2uvkA:
undetectable		 4fwdA-2uvkA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2uvk YJHT
(Escherichia
coli) 		5 / 12 ALA A 110
GLY A  73
ASN A  86
ASN A 167
GLY A 125
 None
 1.20A 4obwD-2uvkA:
undetectable		 4obwD-2uvkA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2uvk YJHT
(Escherichia
coli) 		5 / 8 ALA A 195
PHE A 257
GLY A 246
ALA A 244
GLY A 208
 None
 1.41A 4zjzB-2uvkA:
undetectable		 4zjzB-2uvkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2uvk YJHT
(Escherichia
coli) 		6 / 12 GLY A 125
GLY A 208
GLY A 190
GLU A 209
VAL A 237
ILE A 206
 None
 1.50A 5ec8C-2uvkA:
undetectable		 5ec8C-2uvkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2uvk YJHT
(Escherichia
coli) 		4 / 8 HIS A 290
ASN A 207
GLY A 260
SER A 286
 None
 0.86A 5m8rC-2uvkA:
undetectable		 5m8rC-2uvkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2uvk YJHT
(Escherichia
coli) 		5 / 12 LEU A  48
ILE A  24
TYR A  23
LEU A   3
ASP A  37
 None
 1.31A 6ie8A-2uvkA:
undetectable		 6ie8A-2uvkA:
17.82