SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		5 / 12 GLY B 315
LEU B 311
LEU B 308
VAL B 305
ALA B 251
 None
 1.12A 1gseA-2uw1B:
undetectable		 1gseA-2uw1B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		5 / 12 GLY B 315
LEU B 311
LEU B 308
VAL B 305
ALA B 251
 None
 1.09A 1gseB-2uw1B:
undetectable		 1gseB-2uw1B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		5 / 11 GLU B 138
HIS B 141
GLU B 191
SER B 197
ILE B 220
 FE  B1360 (-2.4A)
FE  B1359 (-3.3A)
FE  B1360 ( 2.0A)
None
None
 0.82A 1rnrA-2uw1B:
14.1		 1rnrA-2uw1B:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.95A 1v54A-2uw1B:
1.1
1v54J-2uw1B:
undetectable		 1v54A-2uw1B:
20.56
1v54J-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 7 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.94A 1v54N-2uw1B:
1.1
1v54W-2uw1B:
undetectable		 1v54N-2uw1B:
20.56
1v54W-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.94A 2dyrA-2uw1B:
undetectable
2dyrJ-2uw1B:
undetectable		 2dyrA-2uw1B:
20.56
2dyrJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.95A 2dysA-2uw1B:
undetectable
2dysJ-2uw1B:
undetectable		 2dysA-2uw1B:
20.56
2dysJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.99A 2dysN-2uw1B:
undetectable
2dysW-2uw1B:
undetectable		 2dysN-2uw1B:
20.56
2dysW-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 1.01A 2eijA-2uw1B:
undetectable
2eijJ-2uw1B:
undetectable		 2eijA-2uw1B:
20.56
2eijJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 7 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 1.00A 2eikA-2uw1B:
undetectable
2eikJ-2uw1B:
undetectable		 2eikA-2uw1B:
20.56
2eikJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.97A 2eilA-2uw1B:
undetectable
2eilJ-2uw1B:
undetectable		 2eilA-2uw1B:
20.56
2eilJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 8 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.89A 2einA-2uw1B:
undetectable
2einJ-2uw1B:
undetectable		 2einA-2uw1B:
20.56
2einJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 4 ASP B 353
ASP B 270
ASP B 156
GLY B 268
 None
 1.27A 2igtC-2uw1B:
undetectable		 2igtC-2uw1B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.97A 2zxwA-2uw1B:
undetectable
2zxwJ-2uw1B:
undetectable		 2zxwA-2uw1B:
20.56
2zxwJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.97A 3abmA-2uw1B:
undetectable
3abmJ-2uw1B:
undetectable		 3abmA-2uw1B:
20.56
3abmJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 1.01A 3asnA-2uw1B:
undetectable
3asnJ-2uw1B:
undetectable		 3asnA-2uw1B:
20.56
3asnJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 1.00A 3asoA-2uw1B:
1.0
3asoJ-2uw1B:
undetectable		 3asoA-2uw1B:
20.56
3asoJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 5 GLN B 190
THR B 187
GLU B 138
THR B 135
 None
GVM  B1362 ( 3.8A)
FE  B1360 (-2.4A)
None
 1.40A 3n58A-2uw1B:
undetectable		 3n58A-2uw1B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		3 / 3 ASP B 313
GLY B 315
ASP B 244
 None
 0.66A 4xdtA-2uw1B:
undetectable		 4xdtA-2uw1B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 7 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.96A 5iy5A-2uw1B:
1.0
5iy5J-2uw1B:
undetectable		 5iy5A-2uw1B:
20.56
5iy5J-2uw1B:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.92A 5x1fA-2uw1B:
undetectable
5x1fJ-2uw1B:
undetectable		 5x1fA-2uw1B:
20.56
5x1fJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		5 / 9 ALA B 249
VAL B 322
ALA B 318
VAL B 305
GLY B 315
 None
 1.23A 6bklA-2uw1B:
undetectable
6bklB-2uw1B:
undetectable
6bklC-2uw1B:
undetectable
6bklD-2uw1B:
undetectable		 6bklA-2uw1B:
6.25
6bklB-2uw1B:
6.25
6bklC-2uw1B:
6.25
6bklD-2uw1B:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE
(Hedera
helix) 		4 / 6 ILE B 185
LEU B 299
VAL B 235
SER B 188
 None
 1.28A 6f6jA-2uw1B:
undetectable		 6f6jA-2uw1B:
undetectable