SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 238
SER A 242
PHE A 133
PHE A 134
 None
 0.82A 1ax9A-2uw2A:
undetectable		 1ax9A-2uw2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		7 / 11 ASP A 138
GLU A 169
HIS A 172
GLU A 232
PHE A 240
ILE A 262
GLU A 266
 None
FE  A1351 (-2.3A)
None
FE  A1351 (-3.4A)
None
None
FE  A1351 (-2.2A)
 0.71A 1rnrA-2uw2A:
30.0		 1rnrA-2uw2A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		6 / 11 ASP A 138
HIS A 172
SER A 239
PHE A 240
ILE A 262
GLU A 266
 None
None
None
None
None
FE  A1351 (-2.2A)
 0.88A 1rnrA-2uw2A:
30.0		 1rnrA-2uw2A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		7 / 12 ASP A 138
GLU A 169
HIS A 172
GLU A 232
PHE A 240
ILE A 262
GLU A 266
 None
FE  A1351 (-2.3A)
None
FE  A1351 (-3.4A)
None
None
FE  A1351 (-2.2A)
 0.58A 1rnrB-2uw2A:
30.0		 1rnrB-2uw2A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		7 / 12 ASP A 138
GLU A 169
HIS A 172
TYR A 176
GLU A 232
ILE A 262
GLU A 266
 None
FE  A1351 (-2.3A)
None
None
FE  A1351 (-3.4A)
None
FE  A1351 (-2.2A)
 0.74A 1rnrB-2uw2A:
30.0		 1rnrB-2uw2A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 335
VAL A 297
ALA A 296
LEU A 331
VAL A 327
 None
 1.20A 2c12C-2uw2A:
3.3		 2c12C-2uw2A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 5 LYS A 278
ILE A  90
PHE A 272
ASP A 271
 None
 0.99A 3kp6A-2uw2A:
undetectable
3kp6B-2uw2A:
0.8		 3kp6A-2uw2A:
21.39
3kp6B-2uw2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		5 / 12 PHE A 244
SER A 258
HIS A 172
TYR A 176
LEU A 131
 None
 1.23A 3vn2A-2uw2A:
undetectable		 3vn2A-2uw2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 269
GLU A 232
LEU A 145
ASP A 138
 FE  A1351 (-3.5A)
FE  A1351 (-3.4A)
None
None
 1.43A 4cevA-2uw2A:
undetectable
4cevB-2uw2A:
undetectable		 4cevA-2uw2A:
22.41
4cevB-2uw2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 6 ASP A 138
HIS A 269
GLU A 232
LEU A 145
 None
FE  A1351 (-3.5A)
FE  A1351 (-3.4A)
None
 1.44A 4cevA-2uw2A:
undetectable
4cevC-2uw2A:
undetectable		 4cevA-2uw2A:
22.41
4cevC-2uw2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 269
GLU A 232
LEU A 145
ASP A 138
 FE  A1351 (-3.5A)
FE  A1351 (-3.4A)
None
None
 1.43A 4cevD-2uw2A:
undetectable
4cevE-2uw2A:
undetectable		 4cevD-2uw2A:
22.41
4cevE-2uw2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 269
GLU A 232
LEU A 145
ASP A 138
 FE  A1351 (-3.5A)
FE  A1351 (-3.4A)
None
None
 1.43A 4cevE-2uw2A:
undetectable
4cevF-2uw2A:
undetectable		 4cevE-2uw2A:
22.41
4cevF-2uw2A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 140
GLY A 139
PHE A 134
PHE A 236
ALA A 210
 None
 1.19A 5n0rA-2uw2A:
undetectable		 5n0rA-2uw2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 140
GLY A 139
PHE A 134
PHE A 236
ALA A 210
 None
 1.22A 5n0xB-2uw2A:
undetectable		 5n0xB-2uw2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 6 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.44A 5ov9A-2uw2A:
undetectable		 5ov9A-2uw2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 7 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.43A 5ov9B-2uw2A:
undetectable		 5ov9B-2uw2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT
(Homo
sapiens) 		4 / 6 ASP A 138
GLN A 165
VAL A 141
ALA A 104
 None
 1.22A 6djzB-2uw2A:
undetectable		 6djzB-2uw2A:
24.13