SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2uwb CELLULASE
(Tropaeolum
majus) 		4 / 4 GLU A 117
TYR A  88
PRO A 172
ASP A  93
 None
 1.49A 1i7zD-2uwbA:
0.1		 1i7zD-2uwbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2uwb CELLULASE
(Tropaeolum
majus) 		4 / 5 SER A  79
TYR A 205
VAL A  76
TYR A  81
 None
 1.08A 2x7hB-2uwbA:
undetectable		 2x7hB-2uwbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uwb CELLULASE
(Tropaeolum
majus) 		4 / 6 ILE A  95
ILE A  66
TYR A 205
LEU A 173
 None
 1.03A 3adsA-2uwbA:
undetectable		 3adsA-2uwbA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 2uwb CELLULASE
(Tropaeolum
majus) 		5 / 11 LEU A  68
TYR A 108
TYR A 205
PHE A  51
ILE A  97
 None
 1.47A 3avoA-2uwbA:
undetectable		 3avoA-2uwbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2uwb CELLULASE
(Tropaeolum
majus) 		5 / 11 LEU A 210
SER A 212
ILE A  66
VAL A 175
LEU A  82
 None
 1.06A 3w67A-2uwbA:
undetectable		 3w67A-2uwbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2uwb CELLULASE
(Tropaeolum
majus) 		5 / 12 ILE A  95
THR A 263
ASP A  93
ILE A 116
ARG A 171
 None
 1.29A 4i41A-2uwbA:
undetectable		 4i41A-2uwbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2uwb CELLULASE
(Tropaeolum
majus) 		5 / 9 TYR A  81
GLU A  94
ASP A  96
GLU A  98
TRP A 180
 None
 0.71A 4ipmA-2uwbA:
11.9		 4ipmA-2uwbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2uwb CELLULASE
(Tropaeolum
majus) 		3 / 3 ASP A  87
TYR A  88
TRP A 174
 None
 1.00A 4p7nA-2uwbA:
undetectable		 4p7nA-2uwbA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2uwb CELLULASE
(Tropaeolum
majus) 		4 / 7 THR A 263
GLU A 265
GLY A 120
TYR A 252
 None
 0.88A 4rdxA-2uwbA:
undetectable		 4rdxA-2uwbA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2uwb CELLULASE
(Tropaeolum
majus) 		4 / 5 LEU A 128
TYR A 108
LEU A 110
TYR A 139
 None
 1.49A 5ki6A-2uwbA:
undetectable		 5ki6A-2uwbA:
14.42