SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 VAL A  98
VAL A 160
TRP A 172
 None
 0.84A 1av2C-2uwfA:
undetectable
1av2D-2uwfA:
undetectable		 1av2C-2uwfA:
3.53
1av2D-2uwfA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 6 PRO A 353
PHE A 290
GLU A 288
GLN A 293
 None
 0.96A 1l2iB-2uwfA:
undetectable		 1l2iB-2uwfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 VAL A  98
VAL A 160
TRP A 172
 None
 0.85A 1w5uC-2uwfA:
undetectable
1w5uD-2uwfA:
undetectable		 1w5uC-2uwfA:
3.53
1w5uD-2uwfA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 VAL A 160
TRP A 172
VAL A  98
 None
 0.85A 2izqA-2uwfA:
undetectable
2izqB-2uwfA:
undetectable		 2izqA-2uwfA:
3.53
2izqB-2uwfA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA156_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 7 GLU A 206
THR A 247
ARG A 296
LEU A 266
 None
 1.49A 2rezA-2uwfA:
0.0		 2rezA-2uwfA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 LYS A 148
LYS A 141
VAL A 144
 None
 1.09A 3brfA-2uwfA:
undetectable		 3brfA-2uwfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		5 / 9 GLN A 291
ASP A 360
ILE A 359
VAL A 351
GLN A  12
 None
CA  A1368 (-3.0A)
None
None
None
 1.25A 3fi0F-2uwfA:
undetectable		 3fi0F-2uwfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 VAL A  98
VAL A 160
TRP A 172
 None
 0.84A 3l8lA-2uwfA:
undetectable
3l8lB-2uwfA:
undetectable		 3l8lA-2uwfA:
3.53
3l8lB-2uwfA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 VAL A  98
VAL A 160
TRP A 172
 None
 0.88A 3l8lC-2uwfA:
undetectable
3l8lD-2uwfA:
undetectable		 3l8lC-2uwfA:
3.53
3l8lD-2uwfA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		5 / 11 ILE A 311
ILE A 237
LEU A 300
VAL A 263
THR A 255
 None
 1.11A 3n0hA-2uwfA:
undetectable		 3n0hA-2uwfA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 6 HIS A 366
HIS A 364
ARG A 357
ASP A 360
 CU  A1367 (-3.2A)
None
None
CA  A1368 (-3.0A)
 0.99A 3nvcA-2uwfA:
undetectable		 3nvcA-2uwfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		5 / 12 ILE A 311
ILE A 237
LEU A 300
VAL A 263
THR A 255
 None
 1.13A 3s3vA-2uwfA:
undetectable		 3s3vA-2uwfA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 5 ASN A 334
ALA A 278
GLY A 338
ASP A 340
 None
 0.97A 4n48A-2uwfA:
undetectable		 4n48A-2uwfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 5 ILE A 319
VAL A  35
PHE A  94
HIS A  51
 None
 1.20A 4rzvA-2uwfA:
undetectable		 4rzvA-2uwfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 5 ASP A 202
VAL A 218
PHE A 254
GLY A 230
 None
 1.09A 4xp6A-2uwfA:
undetectable		 4xp6A-2uwfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		5 / 11 SER A 312
THR A 205
THR A 255
GLY A 232
THR A 264
 None
 1.42A 5bxnV-2uwfA:
undetectable
5bxnb-2uwfA:
undetectable		 5bxnV-2uwfA:
19.24
5bxnb-2uwfA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		5 / 11 SER A 312
THR A 205
THR A 255
GLY A 232
THR A 264
 None
 1.44A 5bxnH-2uwfA:
undetectable
5bxnN-2uwfA:
undetectable		 5bxnH-2uwfA:
19.24
5bxnN-2uwfA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 ARG A 296
PRO A 242
TYR A 304
 None
 0.96A 5tzoB-2uwfA:
undetectable		 5tzoB-2uwfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 4 HIS A  51
VAL A 344
LEU A  21
ALA A  15
 None
 1.35A 6d8pB-2uwfA:
undetectable		 6d8pB-2uwfA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		4 / 5 HIS A 366
ASP A 298
HIS A 362
ARG A 357
 CU  A1367 (-3.2A)
CU  A1367 ( 2.3A)
CU  A1367 (-2.8A)
None
 1.07A 6dchA-2uwfA:
undetectable		 6dchA-2uwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2uwf ALKALINE ACTIVE
ENDOXYLANASE
(Bacillus
halodurans) 		3 / 3 VAL A  35
GLU A  58
ILE A  81
 None
 0.55A 6f7lB-2uwfA:
undetectable		 6f7lB-2uwfA:
21.55