SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		5 / 12 LEU G   5
THR E  68
LEU E  12
LEU E   8
LEU G   9
 None
 0.89A 1mx1C-2uwjG:
undetectable		 1mx1C-2uwjG:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		3 / 3 TRP G  31
ARG G  34
PHE E  49
 NI  E1072 (-4.8A)
None
NI  E1072 (-2.9A)
 1.42A 1zeaH-2uwjG:
undetectable
1zeaL-2uwjG:
undetectable		 1zeaH-2uwjG:
17.51
1zeaL-2uwjG:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2uwj TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		5 / 12 HIS G  80
ASP G  88
LEU G  87
GLY G  84
ALA G  92
 None
 1.19A 2kceB-2uwjG:
undetectable		 2kceB-2uwjG:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2uwj TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		4 / 5 LEU G  91
LEU G  87
LEU G  81
MET G 109
 None
 1.14A 2oaxF-2uwjG:
undetectable		 2oaxF-2uwjG:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2uwj TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		4 / 8 ALA G  10
SER G  47
GLY G  18
ALA G  25
 None
 0.86A 2vh3B-2uwjG:
undetectable		 2vh3B-2uwjG:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		5 / 12 ASP G   2
LEU G   5
ARG G   7
ILE G  28
LEU E  27
 None
 1.12A 3k2hA-2uwjG:
undetectable		 3k2hA-2uwjG:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2uwj TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		3 / 3 GLU G  30
LEU G  26
LEU G  12
 None
 0.75A 3ohtA-2uwjG:
undetectable		 3ohtA-2uwjG:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2uwj TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		5 / 12 LEU G  14
LEU G  70
TRP G  73
ALA G  40
LEU G  32
 None
 1.05A 5ikqA-2uwjG:
undetectable		 5ikqA-2uwjG:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2uwj TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		5 / 12 LEU G  14
LEU G  70
TRP G  73
ALA G  40
LEU G  32
 None
 1.03A 5ikqB-2uwjG:
undetectable		 5ikqB-2uwjG:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2uwj TYPE III EXPORT
PROTEIN PSCE
TYPE III EXPORT
PROTEIN PSCF
TYPE III EXPORT
PROTEIN PSCG
(Pseudomonas
aeruginosa) 		4 / 6 LEU E  27
LEU G   9
LEU F  82
GLU E   9
 None
 0.95A 5tudD-2uwjE:
4.3		 5tudD-2uwjE:
9.98