SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ux8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		3 / 4 LYS A  63
ALA A  65
MET A  31
 None
 0.92A 1hk3A-2ux8A:
undetectable		 1hk3A-2ux8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		4 / 7 PHE A  57
LEU A  95
GLY A  92
ILE A  40
 None
 0.75A 1p2yA-2ux8A:
undetectable		 1p2yA-2ux8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 12 GLU A 161
ARG A 253
ILE A 158
TYR A 208
ASP A 255
 None
G1P  A1290 ( 4.4A)
None
None
G1P  A1290 ( 4.7A)
 1.40A 2qeoA-2ux8A:
undetectable		 2qeoA-2ux8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 10 GLU A 161
ARG A 253
ILE A 158
TYR A 208
ASP A 255
 None
G1P  A1290 ( 4.4A)
None
None
G1P  A1290 ( 4.7A)
 1.40A 2qeoB-2ux8A:
undetectable		 2qeoB-2ux8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 12 ILE A 209
LEU A   6
ILE A  52
ALA A  50
LEU A 130
 None
 1.12A 3a50A-2ux8A:
undetectable		 3a50A-2ux8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		3 / 3 ASP A 134
ARG A 207
ARG A  19
 G1P  A1290 (-3.5A)
None
G1P  A1290 ( 4.9A)
 1.03A 3k37A-2ux8A:
undetectable		 3k37A-2ux8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 10 PRO A  12
HIS A 113
GLY A 112
GLY A  60
ALA A  14
 None
 1.08A 3pp7B-2ux8A:
4.6		 3pp7B-2ux8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		5 / 12 LEU A 130
ALA A 118
VAL A  58
ALA A 114
ILE A  56
 None
 1.08A 4x1kD-2ux8A:
undetectable		 4x1kD-2ux8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		3 / 3 GLY A  15
GLN A 105
LYS A  63
 None
 0.98A 5imsB-2ux8A:
undetectable		 5imsB-2ux8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		4 / 5 PHE A 244
ILE A 158
MET A 235
GLN A 236
 None
 1.19A 5jm4A-2ux8A:
undetectable		 5jm4A-2ux8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		4 / 4 ASP A 133
ILE A  40
PRO A  38
LEU A  39
 None
 1.28A 6mkeB-2ux8A:
undetectable		 6mkeB-2ux8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE
(Sphingomonas
elodea) 		4 / 4 ASP A 133
ILE A  40
PRO A  38
LEU A  39
 None
 1.21A 6mkeA-2ux8A:
undetectable		 6mkeA-2ux8A:
15.19