SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 4 HIS A 138
LEU A 208
LEU A 202
LEU A  93
 None
 1.14A 1a4lD-2uxoA:
undetectable		 1a4lD-2uxoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 8 TYR A 170
LEU A 174
GLU A 192
TRP A 194
 None
 1.09A 1i7zA-2uxoA:
undetectable		 1i7zA-2uxoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.89A 1v55P-2uxoA:
undetectable
1v55W-2uxoA:
undetectable		 1v55P-2uxoA:
21.16
1v55W-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 1.03A 2dysC-2uxoA:
undetectable
2dysJ-2uxoA:
undetectable		 2dysC-2uxoA:
21.16
2dysJ-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.90A 2eijP-2uxoA:
undetectable
2eijW-2uxoA:
undetectable		 2eijP-2uxoA:
21.16
2eijW-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 8 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.93A 2eilP-2uxoA:
undetectable
2eilW-2uxoA:
undetectable		 2eilP-2uxoA:
21.16
2eilW-2uxoA:
15.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		11 / 11 HIS A  67
HIS A  70
ALA A  74
SER A  77
GLU A  78
MET A  89
VAL A  96
CYH A 137
GLY A 140
ILE A 141
VAL A 171
 None
 0.48A 2uxpB-2uxoA:
31.8		 2uxpB-2uxoA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		6 / 11 HIS A  70
ALA A  74
SER A  77
GLU A  78
VAL A  96
VAL A 195
 None
 1.31A 2uxpB-2uxoA:
31.8		 2uxpB-2uxoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 1.00A 2zxwC-2uxoA:
undetectable
2zxwJ-2uxoA:
undetectable		 2zxwC-2uxoA:
21.16
2zxwJ-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 8 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.94A 3asoC-2uxoA:
undetectable
3asoJ-2uxoA:
undetectable		 3asoC-2uxoA:
21.16
3asoJ-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 8 SER A 132
LEU A 135
ASP A 136
LYS A 139
 None
 0.65A 3lsfH-2uxoA:
undetectable		 3lsfH-2uxoA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ILE A 109
GLU A  21
PHE A  24
VAL A  43
 None
 0.89A 4a97A-2uxoA:
undetectable		 4a97A-2uxoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ILE A 109
GLU A  21
PHE A  24
VAL A  43
 None
 0.91A 4a97D-2uxoA:
undetectable		 4a97D-2uxoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 LEU A  92
SER A  77
GLY A 140
ALA A 144
 None
 0.73A 4yjiA-2uxoA:
undetectable		 4yjiA-2uxoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 7 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.83A 5b3sP-2uxoA:
undetectable		 5b3sP-2uxoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		4 / 5 GLN A 128
ARG A 127
CYH A 124
GLU A 125
 None
 1.39A 5fseC-2uxoA:
undetectable		 5fseC-2uxoA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		3 / 3 CYH A 117
LYS A 116
HIS A 115
 None
 0.94A 5js5A-2uxoA:
3.6		 5js5A-2uxoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR
(Pseudomonas
putida) 		5 / 12 LEU A 199
PHE A  97
THR A 197
GLY A 173
LEU A 174
 None
 1.01A 5ogcB-2uxoA:
undetectable		 5ogcB-2uxoA:
21.17