SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  59
GLU A  15
TYR A 133
 None
None
PO4  A1167 (-4.6A)
 0.82A 1wsvA-2uxsA:
undetectable		 1wsvA-2uxsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 140
ARG A  37
ASP A  61
 None
PO4  A1167 (-3.7A)
None
 1.33A 3o7wA-2uxsA:
undetectable		 3o7wA-2uxsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A  36
ASP A  96
GLU A 137
GLU A  25
 PO4  A1167 ( 4.8A)
None
None
None
 1.21A 4fevF-2uxsA:
undetectable		 4fevF-2uxsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A  36
ASP A  96
GLU A 137
GLU A  25
 PO4  A1167 ( 4.8A)
None
None
None
 1.21A 4fexB-2uxsA:
undetectable		 4fexB-2uxsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  36
ASP A  96
GLU A 137
GLU A  25
 PO4  A1167 ( 4.8A)
None
None
None
 1.21A 4gkhB-2uxsA:
undetectable		 4gkhB-2uxsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  36
ASP A  64
GLU A  25
ASP A  59
 PO4  A1167 ( 4.8A)
None
None
None
 1.12A 4gkhC-2uxsA:
undetectable
4gkhK-2uxsA:
undetectable		 4gkhC-2uxsA:
23.10
4gkhK-2uxsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 133
ARG A  37
LYS A 134
 PO4  A1167 (-4.6A)
PO4  A1167 (-3.7A)
PO4  A1167 (-3.3A)
 1.38A 4wq5B-2uxsA:
undetectable		 4wq5B-2uxsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  27
PRO A  62
GLY A  50
GLU A  15
TYR A  49
 None
 1.14A 5hfjD-2uxsA:
undetectable		 5hfjD-2uxsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2uxs INORGANIC
PYROPHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  27
PRO A  62
GLY A  50
GLU A  15
TYR A  49
 None
 1.15A 5hfjF-2uxsA:
undetectable		 5hfjF-2uxsA:
21.60