SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 4 LEU A 130
PRO A 131
LEU A 112
ARG A 118
 None
 1.22A 1hrkB-2uxtA:
undetectable		 1hrkB-2uxtA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 7 GLU A 280
MET A 160
LEU A 162
GLU A 164
 None
 1.14A 1linA-2uxtA:
undetectable		 1linA-2uxtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 8 ASP A 422
ASP A 258
HIS A 142
LEU A 453
 None
 1.04A 1pk2A-2uxtA:
undetectable		 1pk2A-2uxtA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 8 TRP A 425
MET A 455
SER A 460
ALA A 390
 None
 1.01A 2o01A-2uxtA:
undetectable		 2o01A-2uxtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 11 LEU A 233
LEU A 273
GLN A 270
ILE A 186
LEU A 212
 None
 1.28A 2q6hA-2uxtA:
undetectable		 2q6hA-2uxtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 4 LEU A 130
PRO A 131
LEU A 112
ARG A 118
 None
 1.46A 2qd2A-2uxtA:
undetectable		 2qd2A-2uxtA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 11 LEU A 233
LEU A 273
GLN A 270
ILE A 186
LEU A 212
 None
 1.27A 2qeiA-2uxtA:
undetectable		 2qeiA-2uxtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 5 ARG A 118
GLY A 110
PRO A 111
PHE A 444
 None
 1.39A 2rezA-2uxtA:
0.0		 2rezA-2uxtA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 5 ARG A 279
ASP A 417
ILE A 405
GLU A 277
 None
 1.10A 2xrzA-2uxtA:
undetectable
2xrzB-2uxtA:
undetectable		 2xrzA-2uxtA:
21.12
2xrzB-2uxtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		3 / 3 SER A 313
GLU A 392
ASP A 361
 None
 0.72A 2zulA-2uxtA:
undetectable		 2zulA-2uxtA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 8 PHE A 207
GLY A 206
GLU A 392
ALA A 150
 None
 0.69A 3aodA-2uxtA:
undetectable		 3aodA-2uxtA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 12 GLY A 400
GLY A 105
LEU A 106
PRO A 111
VAL A 103
 None
 0.98A 3av6A-2uxtA:
undetectable		 3av6A-2uxtA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 8 GLU A 280
SER A 168
PHE A 261
LEU A 162
 None
 0.99A 3ax7A-2uxtA:
undetectable		 3ax7A-2uxtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		3 / 3 SER A 313
GLU A 392
ASP A 361
 None
 0.75A 3dmhA-2uxtA:
undetectable		 3dmhA-2uxtA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 9 GLY A  84
ASP A  86
VAL A  81
VAL A 163
GLN A 134
 None
 1.10A 3fi0O-2uxtA:
undetectable		 3fi0O-2uxtA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 8 GLU A 280
SER A 168
PHE A 261
LEU A 162
 None
 0.93A 3ns1L-2uxtA:
undetectable		 3ns1L-2uxtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 12 LEU A 282
PHE A 182
LEU A 231
GLY A 227
ASP A 181
 None
 1.36A 3tbgA-2uxtA:
undetectable		 3tbgA-2uxtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 12 TYR A 199
GLY A 156
LEU A 213
GLY A 216
ALA A 143
 None
 0.94A 3vywC-2uxtA:
undetectable		 3vywC-2uxtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 12 ALA A 378
VAL A 376
PHE A 396
ILE A 356
PHE A 448
 None
 1.30A 4c49A-2uxtA:
undetectable		 4c49A-2uxtA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 12 GLY A 206
GLY A 205
SER A 239
ASP A 188
ALA A 274
 None
 1.13A 4uckB-2uxtA:
undetectable		 4uckB-2uxtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 8 ILE A 293
SER A 317
LEU A 213
ILE A 186
 None
 0.97A 4xtaB-2uxtA:
undetectable		 4xtaB-2uxtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		4 / 6 ASP A 391
ARG A 389
ASN A 409
GLN A 429
 None
 1.23A 5l6eA-2uxtA:
undetectable		 5l6eA-2uxtA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		3 / 3 VAL A 430
VAL A 388
GLN A 394
 None
 0.71A 5qh9A-2uxtA:
undetectable		 5qh9A-2uxtA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		3 / 3 VAL A 430
VAL A 388
GLN A 394
 None
 0.72A 5qhfA-2uxtA:
undetectable		 5qhfA-2uxtA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 12 GLY A 205
GLY A 203
PHE A 207
THR A 452
TYR A 199
 None
 1.26A 5yf0A-2uxtA:
undetectable		 5yf0A-2uxtA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2uxt PROTEIN SUFI
(Escherichia
coli) 		5 / 9 GLY A  69
TYR A 141
VAL A  52
MET A  50
GLY A 156
 None
 1.25A 5zniA-2uxtA:
undetectable		 5zniA-2uxtA:
9.98