SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 121
VAL A  99
GLY A  98
VAL A  13
VAL A  15
 None
 1.28A 1akdA-2uxyA:
undetectable		 1akdA-2uxyA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 183
GLU A 184
LEU A 185
VAL A 187
 None
 0.90A 1hk2A-2uxyA:
undetectable		 1hk2A-2uxyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 121
VAL A  99
GLY A  98
VAL A  13
VAL A  15
 None
 1.39A 2cp4A-2uxyA:
undetectable		 2cp4A-2uxyA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A  75
GLN A  63
TYR A  60
TRP A 144
 None
None
C3Y  A 166 ( 4.9A)
None
 1.40A 2xz5A-2uxyA:
undetectable
2xz5C-2uxyA:
undetectable		 2xz5A-2uxyA:
21.16
2xz5C-2uxyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		5 / 8 LEU A 258
ILE A 235
TYR A 255
ARG A   2
GLY A   4
 None
 1.48A 3b9lA-2uxyA:
undetectable		 3b9lA-2uxyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 119
ASP A 168
SER A 101
THR A 103
 None
 0.80A 3dzgB-2uxyA:
undetectable		 3dzgB-2uxyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  59
GLU A 142
TYR A 192
TYR A  60
 C3Y  A 166 ( 2.8A)
C3Y  A 166 ( 3.4A)
C3Y  A 166 ( 3.3A)
C3Y  A 166 ( 4.9A)
 1.15A 3ku9B-2uxyA:
undetectable		 3ku9B-2uxyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 256
ARG A   2
SER A   8
TYR A 255
VAL A  17
 None
 1.31A 3qxvE-2uxyA:
undetectable		 3qxvE-2uxyA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		5 / 12 CYH A  91
ALA A  39
GLY A  44
ILE A  86
GLY A 126
 None
None
None
SO4  A1343 ( 4.2A)
None
 1.13A 5wwsB-2uxyA:
undetectable		 5wwsB-2uxyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 190
TYR A 192
ASN A 219
 C3Y  A 166 ( 4.8A)
C3Y  A 166 ( 3.3A)
None
 1.00A 6dwdC-2uxyA:
undetectable		 6dwdC-2uxyA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2uxy ALIPHATIC AMIDASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 201
ILE A 236
GLY A  98
ALA A 218
 None
 0.91A 6hd6B-2uxyA:
undetectable		 6hd6B-2uxyA:
11.28