SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		4 / 8 MET A 198
GLU A 184
ASP A 180
ARG A 177
 None
 1.19A 1dtlA-2uy1A:
undetectable		 1dtlA-2uy1A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		4 / 5 PHE A 327
LEU A 449
PHE A 343
SER A 353
 None
 0.92A 1wrkB-2uy1A:
undetectable		 1wrkB-2uy1A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		4 / 6 GLN A 228
GLY A 227
HIS A 199
HIS A 202
 None
 1.33A 3ai8B-2uy1A:
undetectable		 3ai8B-2uy1A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		4 / 8 TYR A  91
GLU A  95
TYR A  88
ILE A  54
 None
 0.73A 3jz0B-2uy1A:
undetectable		 3jz0B-2uy1A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		4 / 5 TYR A 330
PHE A 363
PRO A 339
LEU A 364
 None
 1.49A 3tgvC-2uy1A:
undetectable		 3tgvC-2uy1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		3 / 3 TYR A 112
GLU A  72
TYR A  68
 None
 1.01A 3ug8A-2uy1A:
undetectable		 3ug8A-2uy1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		5 / 9 ASP A 369
TYR A 340
SER A 344
PHE A 360
LEU A 364
 None
 1.36A 4y4jA-2uy1A:
undetectable		 4y4jA-2uy1A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		3 / 3 PHE A  78
ASP A  83
LEU A 116
 None
 0.56A 5uhbC-2uy1A:
undetectable		 5uhbC-2uy1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		3 / 3 PHE A  78
ASP A  83
LEU A 116
 None
 0.59A 5uhcC-2uy1A:
undetectable		 5uhcC-2uy1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 2uy1 CLEAVAGE STIMULATION
FACTOR 77
(Encephalitozoon
cuniculi) 		5 / 12 GLU A 213
TYR A 439
LEU A 436
MET A 432
ASP A 461
 None
 1.49A 6ag0C-2uy1A:
undetectable		 6ag0C-2uy1A:
8.70