SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.00A 1ddrA-2uy3A:
undetectable		 1ddrA-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.99A 1ddrB-2uy3A:
undetectable		 1ddrB-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.99A 1ddsA-2uy3A:
undetectable		 1ddsA-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.00A 1dyiA-2uy3A:
undetectable		 1dyiA-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.01A 1jolA-2uy3A:
undetectable		 1jolA-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 175
PHE A 152
GLU A 135
GLY A 134
 None
 1.10A 1kqbA-2uy3A:
undetectable
1kqbB-2uy3A:
undetectable		 1kqbA-2uy3A:
24.27
1kqbB-2uy3A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 175
PHE A 152
GLU A 135
GLY A 134
 None
 1.08A 1kqbC-2uy3A:
undetectable
1kqbD-2uy3A:
undetectable		 1kqbC-2uy3A:
24.27
1kqbD-2uy3A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.00A 1rb2A-2uy3A:
undetectable		 1rb2A-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.96A 1rb3B-2uy3A:
undetectable		 1rb3B-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.96A 1rd7A-2uy3A:
undetectable		 1rd7A-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.00A 1rx8A-2uy3A:
undetectable		 1rx8A-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 155
ASP A 286
GLY A 247
ILE A 211
 H33  A1311 (-3.0A)
None
None
None
 0.83A 1t7iB-2uy3A:
undetectable		 1t7iB-2uy3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 155
ASP A 286
GLY A 247
ILE A 211
 H33  A1311 (-3.0A)
None
None
None
 0.80A 1t7jB-2uy3A:
undetectable		 1t7jB-2uy3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A  32
PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.62A 2a3aA-2uy3A:
20.2		 2a3aA-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 9 PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.66A 2a3aB-2uy3A:
20.3		 2a3aB-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 10 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3bB-2uy3A:
20.2		 2a3bB-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		7 / 12 TYR A  32
PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3cA-2uy3A:
20.2		 2a3cA-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 12 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3cB-2uy3A:
20.2		 2a3cB-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  71
LEU A 105
LEU A  67
LEU A  83
 None
 0.94A 2bfpB-2uy3A:
3.5		 2bfpB-2uy3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  71
LEU A 105
LEU A  67
LEU A  83
 None
 0.84A 2bfpC-2uy3A:
3.5		 2bfpC-2uy3A:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		9 / 9 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
GLU A 157
GLN A 212
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-3.3A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.20A 2uy4A-2uy3A:
52.5		 2uy4A-2uy3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 GLY A 109
ALA A 110
GLU A 157
GLN A 189
ASN A 215
ALA A 255
 H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.7A)
None
None
H33  A1311 ( 4.6A)
 1.38A 2xtkA-2uy3A:
40.6		 2xtkA-2uy3A:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		7 / 11 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
ALA A 254
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
None
H33  A1311 (-3.5A)
 1.14A 2xtkA-2uy3A:
40.6		 2xtkA-2uy3A:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		11 / 11 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
GLU A 157
GLN A 212
TYR A 214
ASN A 215
ALA A 255
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-3.3A)
H33  A1311 (-4.7A)
None
H33  A1311 ( 4.6A)
H33  A1311 (-3.5A)
 0.43A 2xtkA-2uy3A:
40.6		 2xtkA-2uy3A:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		9 / 10 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
GLU A 157
GLN A 212
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-3.3A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.33A 2xtkB-2uy3A:
40.5		 2xtkB-2uy3A:
42.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A  32
PHE A  60
GLY A 109
ASP A 155
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.98A 3g6mA-2uy3A:
20.3		 3g6mA-2uy3A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A  32
PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.66A 3g6mA-2uy3A:
20.3		 3g6mA-2uy3A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 214
ALA A 254
GLY A 256
SER A 257
ALA A 290
 H33  A1311 (-4.7A)
None
None
None
None
 1.14A 3ou6C-2uy3A:
undetectable		 3ou6C-2uy3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 214
ALA A 254
GLY A 256
SER A 257
ALA A 290
 H33  A1311 (-4.7A)
None
None
None
None
 1.16A 3ou7C-2uy3A:
undetectable		 3ou7C-2uy3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.99A 3ql0A-2uy3A:
undetectable		 3ql0A-2uy3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.56A 3wqvA-2uy3A:
20.0		 3wqvA-2uy3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.58A 3wqwA-2uy3A:
20.1		 3wqwA-2uy3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.97A 4ej1A-2uy3A:
undetectable		 4ej1A-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.93A 4ej1B-2uy3A:
undetectable		 4ej1B-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 208
PHE A 245
PHE A 210
LEU A  57
 None
 0.91A 4ejgC-2uy3A:
undetectable		 4ejgC-2uy3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.10A 4gh8A-2uy3A:
undetectable		 4gh8A-2uy3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.01A 4i13A-2uy3A:
undetectable		 4i13A-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.97A 4psyA-2uy3A:
undetectable		 4psyA-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.89A 4qi9A-2uy3A:
undetectable		 4qi9A-2uy3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.92A 4qi9B-2uy3A:
undetectable		 4qi9B-2uy3A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.97A 4qleA-2uy3A:
undetectable		 4qleA-2uy3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.98A 4qleB-2uy3A:
undetectable		 4qleB-2uy3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.99A 4qlgA-2uy3A:
undetectable		 4qlgA-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.04A 4qlgB-2uy3A:
undetectable		 4qlgB-2uy3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 154
GLY A 108
SER A  59
ASN A 158
ASP A 153
 None
 1.31A 4rtpA-2uy3A:
undetectable		 4rtpA-2uy3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.01A 4x5fA-2uy3A:
undetectable		 4x5fA-2uy3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.04A 4x5fB-2uy3A:
undetectable		 4x5fB-2uy3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.00A 4x5hA-2uy3A:
undetectable		 4x5hA-2uy3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.88A 4x5iA-2uy3A:
undetectable		 4x5iA-2uy3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 200
LEU A 201
GLY A 198
SER A 196
ILE A 206
 None
 1.05A 4xj7C-2uy3A:
undetectable
4xj7D-2uy3A:
undetectable		 4xj7C-2uy3A:
22.05
4xj7D-2uy3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 194
SER A 196
ASN A 159
TYR A 217
ASN A 216
 None
 1.43A 5d0yA-2uy3A:
undetectable		 5d0yA-2uy3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 194
SER A 196
ASN A 159
TYR A 217
ASN A 216
 None
 1.43A 5d0yB-2uy3A:
0.0		 5d0yB-2uy3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 201
ASP A 207
LEU A 184
LEU A 200
ALA A 168
 None
 1.08A 5dqfA-2uy3A:
undetectable		 5dqfA-2uy3A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.02A 5e8qB-2uy3A:
undetectable		 5e8qB-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.01A 5eajB-2uy3A:
undetectable		 5eajB-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 8 PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.60A 5gqbA-2uy3A:
18.7		 5gqbA-2uy3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 0.99A 5hi6A-2uy3A:
undetectable		 5hi6A-2uy3A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.01A 5hi6B-2uy3A:
undetectable		 5hi6B-2uy3A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 200
LEU A 167
THR A 169
ALA A 168
 None
 0.77A 5o96C-2uy3A:
undetectable		 5o96C-2uy3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
ALA A 271
LEU A 307
ILE A 260
LEU A 248
 None
 1.03A 5ujxB-2uy3A:
undetectable		 5ujxB-2uy3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 132
ARG A 142
LYS A 170
LEU A 200
PHE A 154
 None
 1.29A 5ybbB-2uy3A:
undetectable		 5ybbB-2uy3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  67
GLN A  63
PHE A  64
PHE A 144
 None
 1.36A 6nmpP-2uy3A:
undetectable
6nmpW-2uy3A:
undetectable		 6nmpP-2uy3A:
18.03
6nmpW-2uy3A:
11.97