SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 12 PHE A  90
PHE A  99
PHE A 298
LEU A 115
ALA A 123
 None
 1.35A 1q23D-2uyeA:
undetectable
1q23E-2uyeA:
undetectable		 1q23D-2uyeA:
21.43
1q23E-2uyeA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		7 / 11 THR A 104
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.92A 2y7kA-2uyeA:
30.2		 2y7kA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		7 / 11 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
None
SCN  A1303 (-4.1A)
 0.86A 2y7kA-2uyeA:
30.2		 2y7kA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		7 / 7 PRO A  92
SER A  95
PHE A  99
ILE A 126
PRO A 285
GLY A 286
TRP A 289
 None
 0.42A 2y7kA-2uyeA:
30.2		 2y7kA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 10 THR A 104
GLY A 107
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.89A 2y7kB-2uyeA:
30.5		 2y7kB-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 10 THR A 104
ILE A 106
GLY A 107
PHE A 167
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1303 (-4.7A)
None
SCN  A1303 (-4.1A)
 0.82A 2y7kB-2uyeA:
30.5		 2y7kB-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 5 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.36A 2y7kB-2uyeA:
30.5		 2y7kB-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 12 GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.4A)
None
SCN  A1303 (-4.1A)
 1.22A 2y7kC-2uyeA:
32.6		 2y7kC-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		8 / 12 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.77A 2y7kC-2uyeA:
32.6		 2y7kC-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 12 GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.4A)
None
SCN  A1303 (-4.1A)
 1.23A 2y7kD-2uyeA:
31.6		 2y7kD-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		8 / 12 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.71A 2y7kD-2uyeA:
31.6		 2y7kD-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 10 GLY A 152
PHE A 167
HIS A 169
PRO A 246
ILE A 273
 SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.4A)
None
SCN  A1303 (-4.1A)
 1.31A 2y7pA-2uyeA:
30.1		 2y7pA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		7 / 10 THR A 104
GLY A 107
GLY A 152
PHE A 167
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.94A 2y7pA-2uyeA:
30.1		 2y7pA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		7 / 10 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
None
SCN  A1303 (-4.1A)
 0.92A 2y7pA-2uyeA:
30.1		 2y7pA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 6 SER A  95
ARG A  97
PRO A 285
GLY A 286
TRP A 289
 None
 0.38A 2y7pA-2uyeA:
20.9		 2y7pA-2uyeA:
70.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 9 THR A 104
ILE A 106
GLY A 107
GLY A 152
PHE A 167
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.1A)
 0.59A 2y7wA-2uyeA:
20.4		 2y7wA-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 10 THR A 104
GLY A 107
GLY A 152
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.74A 2y7wB-2uyeA:
30.7		 2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 10 THR A 104
GLY A 107
THR A 204
HIS A 206
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 (-3.5A)
SCN  A1309 ( 4.7A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.90A 2y7wB-2uyeA:
30.7		 2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 10 THR A 104
ILE A 106
GLY A 107
GLY A 152
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1307 (-3.6A)
None
SCN  A1303 (-4.1A)
 0.33A 2y7wB-2uyeA:
30.7		 2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		6 / 10 THR A 104
ILE A 106
GLY A 107
THR A 204
PRO A 246
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1309 ( 4.7A)
None
SCN  A1303 (-4.1A)
 0.56A 2y7wB-2uyeA:
30.7		 2y7wB-2uyeA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 7 THR A 104
ILE A 106
GLY A 107
PHE A 167
ILE A 273
 SCN  A1307 (-4.0A)
SCN  A1303 ( 4.9A)
SCN  A1303 (-3.5A)
SCN  A1303 (-4.7A)
SCN  A1303 (-4.1A)
 0.64A 2y7wC-2uyeA:
30.7		 2y7wC-2uyeA:
73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 12 LEU A 151
THR A 104
PHE A 167
GLU A 300
HIS A 206
 None
SCN  A1307 (-4.0A)
SCN  A1303 (-4.7A)
None
SCN  A1307 (-3.6A)
 0.98A 2ydoA-2uyeA:
undetectable		 2ydoA-2uyeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		4 / 8 LEU A 151
ILE A 273
HIS A 169
GLY A 205
 None
SCN  A1303 (-4.1A)
SCN  A1303 (-4.4A)
SCN  A1307 (-3.5A)
 0.96A 3b9lA-2uyeA:
undetectable		 3b9lA-2uyeA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		3 / 3 PHE A 249
CYH A 253
PHE A 257
 SCN  A1305 (-4.8A)
SCN  A1305 ( 4.1A)
None
 1.13A 3cr5X-2uyeA:
undetectable		 3cr5X-2uyeA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		4 / 6 PHE A 175
HIS A 196
MET A 186
LEU A 241
 None
None
None
GOL  A1312 (-4.2A)
 1.37A 5dzka-2uyeA:
undetectable
5dzko-2uyeA:
undetectable		 5dzka-2uyeA:
22.04
5dzko-2uyeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		5 / 9 LEU A 213
ILE A 218
GLY A 217
LEU A 268
ALA A 266
 SCN  A1306 ( 4.9A)
None
None
SCN  A1306 ( 4.5A)
SCN  A1306 ( 4.1A)
 0.93A 5o96A-2uyeA:
undetectable
5o96B-2uyeA:
undetectable		 5o96A-2uyeA:
20.51
5o96B-2uyeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		4 / 7 ILE A 235
LEU A 236
MET A 174
LEU A 259
 None
 0.96A 5u4sA-2uyeA:
undetectable		 5u4sA-2uyeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2uye REGULATORY PROTEIN
(Burkholderia
cepacia) 		4 / 8 ILE A 235
LEU A 236
MET A 174
LEU A 259
 None
 0.93A 5u4sB-2uyeA:
undetectable		 5u4sB-2uyeA:
23.42