SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		4 / 5 LEU A 100
VAL A  20
ARG A 110
THR A 101
 GOL  A1143 (-4.6A)
None
GOL  A1143 ( 4.9A)
GOL  A1143 ( 4.1A)
 1.27A 1nw3A-2uygA:
undetectable		 1nw3A-2uygA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		3 / 3 LEU A  72
HIS A  99
ILE A 122
 None
GOL  A1143 (-4.1A)
None
 0.69A 1s9pB-2uygA:
undetectable		 1s9pB-2uygA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		5 / 12 VAL A  95
ILE A   4
ASN A   6
LEU A  10
ALA A 134
 None
None
None
GOL  A1143 (-4.6A)
None
 1.43A 2iyfB-2uygA:
3.9		 2iyfB-2uygA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		5 / 10 VAL A  98
VAL A  71
ILE A   4
LEU A  13
LEU A  10
 None
None
None
None
GOL  A1143 (-4.6A)
 1.41A 4jtqA-2uygA:
1.7		 4jtqA-2uygA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		5 / 11 VAL A  95
ILE A   4
ASN A   6
LEU A  10
ALA A 134
 None
None
None
GOL  A1143 (-4.6A)
None
 1.42A 4m83A-2uygA:
undetectable		 4m83A-2uygA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		3 / 3 VAL A  71
TYR A 131
ALA A 134
 None
 0.42A 4ybnA-2uygA:
undetectable		 4ybnA-2uygA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2uyg 3-DEHYDROQUINATE
DEHYDRATASE
(Thermus
thermophilus) 		4 / 5 PRO A   8
GLY A   7
THR A  49
ASN A   6
 None
 1.13A 5x23A-2uygA:
undetectable		 5x23A-2uygA:
15.99