SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 THR A  17
GLY A 112
LEU A 162
LEU A 188
TYR A 191
 None
 0.72A 1rjdA-2uyoA:
23.3		 1rjdA-2uyoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 THR A  17
GLY A 112
LEU A 162
LEU A 188
TYR A 191
 None
 0.78A 1rjdB-2uyoA:
23.3		 1rjdB-2uyoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 THR A  17
GLY A 112
LEU A 162
LEU A 188
TYR A 191
 None
 0.77A 1rjdC-2uyoA:
23.3		 1rjdC-2uyoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 7 PHE A 175
ARG A 171
ASP A 176
ALA A 209
 None
 0.95A 2e5dA-2uyoA:
undetectable
2e5dB-2uyoA:
2.1		 2e5dA-2uyoA:
20.77
2e5dB-2uyoA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 7 PHE A 175
ARG A 171
ASP A 176
ALA A 209
 None
 0.95A 2e5dA-2uyoA:
undetectable
2e5dB-2uyoA:
2.3		 2e5dA-2uyoA:
20.77
2e5dB-2uyoA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 6 ARG A 163
GLU A 203
PRO A 167
ALA A 169
 None
 1.40A 2ejfB-2uyoA:
undetectable		 2ejfB-2uyoA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		7 / 7 ALA A 110
GLY A 112
ASP A 132
VAL A 136
ASP A 161
LEU A 162
ARG A 163
 None
 0.46A 2uyqA-2uyoA:
47.6		 2uyqA-2uyoA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 ALA A 278
PRO A 220
GLY A 187
THR A  17
VAL A 216
 None
 1.23A 2zifA-2uyoA:
2.3		 2zifA-2uyoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 8 THR A  17
ARG A  87
ASP A 132
ASP A 161
GLU A 186
 None
 1.07A 2zw9A-2uyoA:
21.1		 2zw9A-2uyoA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		6 / 12 THR A  17
GLY A 112
ASP A 114
LEU A 162
GLU A 186
TYR A 191
 None
 0.91A 2zw9B-2uyoA:
10.9		 2zw9B-2uyoA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 THR A  17
GLY A 112
ASP A 161
LEU A 162
TYR A 191
 None
 0.80A 2zw9B-2uyoA:
10.9		 2zw9B-2uyoA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 4 LEU A 189
ARG A 268
LEU A 266
ALA A 260
 None
 1.21A 3b9mA-2uyoA:
undetectable		 3b9mA-2uyoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 4 VAL A 107
ARG A 171
ILE A 160
THR A 127
 None
 1.16A 3cl9A-2uyoA:
undetectable		 3cl9A-2uyoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		3 / 3 LEU A 221
GLU A 303
SER A 219
 None
 0.71A 4ccqA-2uyoA:
2.8		 4ccqA-2uyoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 8 PHE A 175
ARG A 171
ASP A 176
ALA A 209
SER A 212
 None
 1.11A 4lv9A-2uyoA:
undetectable
4lv9B-2uyoA:
undetectable		 4lv9A-2uyoA:
21.13
4lv9B-2uyoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 7 PHE A 175
ASP A 176
ALA A 209
SER A 212
 None
 1.13A 4lv9A-2uyoA:
undetectable
4lv9B-2uyoA:
undetectable		 4lv9A-2uyoA:
21.13
4lv9B-2uyoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 4 LEU A 188
SER A 111
LEU A 184
LEU A 200
 None
 1.06A 4n09A-2uyoA:
undetectable		 4n09A-2uyoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 6 LEU A 144
ASP A 114
GLU A 157
ALA A 153
 None
 1.01A 4nkvC-2uyoA:
undetectable		 4nkvC-2uyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 8 HIS A  79
TYR A  83
PRO A 220
TYR A 191
 None
 1.12A 5v4vA-2uyoA:
undetectable		 5v4vA-2uyoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 8 HIS A  79
TYR A  83
PRO A 220
TYR A 191
 None
 1.13A 5v4vB-2uyoA:
undetectable		 5v4vB-2uyoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 ASP A  38
PHE A  91
LEU A 189
ILE A 214
ILE A 131
 None
 1.12A 5vc0A-2uyoA:
undetectable		 5vc0A-2uyoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		4 / 5 VAL A 107
THR A 181
LEU A 162
LEU A 189
 None
 0.98A 6bqgA-2uyoA:
undetectable		 6bqgA-2uyoA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 TYR A 118
ILE A 108
ASP A 114
ARG A  25
ASP A  38
 None
 1.31A 6c9zA-2uyoA:
undetectable		 6c9zA-2uyoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 2uyo HYPOTHETICAL PROTEIN
ML2640
(Mycobacterium
leprae) 		5 / 12 TYR A 118
ILE A 108
ASP A 114
ARG A  25
ASP A  38
 None
 1.32A 6ca3A-2uyoA:
undetectable		 6ca3A-2uyoA:
13.85