SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		4 / 7 CYH A 413
PHE A 272
PHE A 417
LEU A 399
 None
 1.08A 1qcaA-2uyyA:
undetectable		 1qcaA-2uyyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		5 / 12 MET A 360
ILE A 326
SER A 415
PHE A 417
ILE A 401
 None
 1.37A 1xotA-2uyyA:
undetectable		 1xotA-2uyyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		5 / 11 HIS A 291
SER A 394
GLY A 421
ILE A 401
VAL A 358
 None
None
K  A1554 (-4.2A)
None
None
 1.21A 2uxpB-2uyyA:
undetectable		 2uxpB-2uyyA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		4 / 8 THR A 327
TYR A 357
ARG A 352
ILE A 351
 None
 1.03A 2xytE-2uyyA:
undetectable		 2xytE-2uyyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		4 / 8 THR A 327
TYR A 357
ARG A 352
ILE A 351
 None
 1.01A 2xytH-2uyyA:
undetectable		 2xytH-2uyyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 385
SER A 414
PHE A 417
GLY A 421
VAL A 400
 None
None
None
K  A1554 (-4.2A)
None
 1.13A 2zifB-2uyyA:
2.1		 2zifB-2uyyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 547
TYR A 551
TYR A 531
ILE A 451
 None
 1.07A 3q5sA-2uyyA:
undetectable		 3q5sA-2uyyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 277
SER A 280
ASN A 285
GLY A 397
ASP A 396
 NA7  A1555 (-3.2A)
None
None
K  A1554 (-4.3A)
None
 1.26A 3sfuC-2uyyA:
undetectable		 3sfuC-2uyyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 543
ASN A 390
MET A 437
MET A 448
GLY A 445
 None
 1.37A 4af0B-2uyyA:
undetectable		 4af0B-2uyyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2uyy N-PAC PROTEIN
(Homo
sapiens) 		4 / 5 VAL A 400
LEU A 399
SER A 388
MET A 360
 None
 1.32A 4e1gA-2uyyA:
undetectable		 4e1gA-2uyyA:
18.96