SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 10 GLY A  44
SER A 120
MET A 121
LEU A 204
HIS A 231
 GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
GOL  A1259 (-3.9A)
 0.80A 1a8uA-2uz0A:
14.7		 1a8uA-2uz0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 10 GLY A  44
SER A 120
MET A 121
LEU A 204
HIS A 231
 GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
GOL  A1259 (-3.9A)
 0.75A 1a8uB-2uz0A:
14.6		 1a8uB-2uz0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 163
GLY A  44
SER A 120
GLY A 144
LEU A 204
 None
GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
 1.12A 1fe2A-2uz0A:
undetectable		 1fe2A-2uz0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 163
GLY A  44
SER A 120
GLY A 144
LEU A 204
 None
GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
None
 1.06A 1igxA-2uz0A:
undetectable		 1igxA-2uz0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 7 TYR A 163
TRP A  78
TYR A 124
GLY A 118
 None
 1.31A 1mxgA-2uz0A:
undetectable		 1mxgA-2uz0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 144
ILE A 116
LEU A  42
GLY A 122
GLY A 123
 None
 0.93A 1uakA-2uz0A:
undetectable		 1uakA-2uz0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 6 TRP A 233
GLY A 123
PHE A 142
SER A 141
 GOL  A1259 ( 4.8A)
None
None
None
 1.37A 2a3cA-2uz0A:
undetectable		 2a3cA-2uz0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 6 TRP A 233
GLY A 123
PHE A 142
SER A 141
 GOL  A1259 ( 4.8A)
None
None
None
 1.36A 2a3cB-2uz0A:
undetectable		 2a3cB-2uz0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 7 ARG A 111
ARG A 135
ILE A 116
PHE A 243
 None
 1.04A 2q6hA-2uz0A:
undetectable		 2q6hA-2uz0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 127
GLY A 125
ILE A 116
ALA A 130
 None
 0.84A 3aodA-2uz0A:
undetectable		 3aodA-2uz0A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 146
ALA A 211
LYS A 213
LEU A 215
ALA A 185
 None
 1.25A 3e22B-2uz0A:
2.8		 3e22B-2uz0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 146
ALA A 211
LYS A 213
LEU A 215
ALA A 185
 None
 1.26A 3e22D-2uz0A:
3.3		 3e22D-2uz0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 7 GLY A  44
SER A 120
LEU A 158
HIS A 231
 GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
GOL  A1259 (-3.9A)
 0.69A 3o9mA-2uz0A:
15.5		 3o9mA-2uz0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A  44
SER A 120
LEU A 158
HIS A 231
 GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
GOL  A1259 (-3.9A)
 0.76A 3o9mB-2uz0A:
15.5		 3o9mB-2uz0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A  87
ALA A  91
ASP A  81
TYR A  84
 None
 1.20A 3rodD-2uz0A:
undetectable		 3rodD-2uz0A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 5 GLY A 159
MET A 121
PHE A 168
ASN A  76
 None
 1.20A 3uq6B-2uz0A:
undetectable		 3uq6B-2uz0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 4 LEU A 158
GLY A 159
MET A 121
PHE A 148
 None
 1.44A 3vaqB-2uz0A:
4.6		 3vaqB-2uz0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A  79
GLY A 118
GLY A 122
TYR A 124
LEU A  39
 None
 1.04A 3vywA-2uz0A:
undetectable		 3vywA-2uz0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A 124
TRP A  78
VAL A 167
TYR A 179
 None
 1.28A 4bqtC-2uz0A:
undetectable
4bqtD-2uz0A:
undetectable		 4bqtC-2uz0A:
22.10
4bqtD-2uz0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 139
ALA A 185
ASN A 208
LEU A 146
GLY A 123
 None
 0.96A 4r38A-2uz0A:
undetectable		 4r38A-2uz0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 139
ALA A 185
ASN A 208
LEU A 146
GLY A 123
 None
 0.98A 4r38B-2uz0A:
undetectable		 4r38B-2uz0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 139
ALA A 185
ASN A 208
LEU A 146
GLY A 123
 None
 0.97A 4r38C-2uz0A:
undetectable		 4r38C-2uz0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 139
ALA A 185
ASN A 208
LEU A 146
GLY A 123
 None
 0.97A 4r38D-2uz0A:
undetectable		 4r38D-2uz0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 PHE A 142
LEU A 240
GLY A 118
CYH A 126
LEU A  39
 None
 1.28A 4zbrA-2uz0A:
undetectable		 4zbrA-2uz0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 215
GLY A 144
ALA A 211
LEU A 181
GLY A 199
 None
 0.93A 5kb5A-2uz0A:
undetectable		 5kb5A-2uz0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 SER A 177
GLY A 123
ILE A 171
PHE A 168
GLY A 125
 None
 1.05A 5veuH-2uz0A:
undetectable		 5veuH-2uz0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 144
ILE A 116
LEU A  42
GLY A 122
GLY A 123
 None
 0.93A 5wyqB-2uz0A:
undetectable		 5wyqB-2uz0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 119
THR A  74
ASN A  73
 None
None
EDO  A1261 (-3.5A)
 0.68A 6baaE-2uz0A:
undetectable		 6baaE-2uz0A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 119
THR A  74
ASN A  73
 None
None
EDO  A1261 (-3.5A)
 0.67A 6baaF-2uz0A:
undetectable		 6baaF-2uz0A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 119
THR A  74
ASN A  73
 None
None
EDO  A1261 (-3.5A)
 0.68A 6baaG-2uz0A:
undetectable		 6baaG-2uz0A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2uz0 TRIBUTYRIN ESTERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 119
THR A  74
ASN A  73
 None
None
EDO  A1261 (-3.5A)
 0.68A 6baaH-2uz0A:
undetectable		 6baaH-2uz0A:
10.63