SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2uzf NAPHTHOATE SYNTHASE
(Staphylococcus
aureus) 		4 / 6 ASP A  76
GLY A  75
THR A  38
PRO A  39
 None
CAA  A1274 (-3.1A)
None
None
 0.96A 1n4fA-2uzfA:
undetectable		 1n4fA-2uzfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2uzf NAPHTHOATE SYNTHASE
(Staphylococcus
aureus) 		3 / 3 GLY A 122
GLY A 141
GLY A 120
 None
None
CAA  A1274 ( 4.3A)
 0.41A 3bogC-2uzfA:
undetectable		 3bogC-2uzfA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2uzf NAPHTHOATE SYNTHASE
(Staphylococcus
aureus) 		4 / 7 ALA A 134
PHE A 140
ALA A 118
ALA A 112
 None
 0.92A 4du2A-2uzfA:
undetectable		 4du2A-2uzfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2uzf NAPHTHOATE SYNTHASE
(Staphylococcus
aureus) 		4 / 7 ALA A 134
PHE A 140
ALA A 118
ALA A 112
 None
 0.81A 4du2B-2uzfA:
undetectable		 4du2B-2uzfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 2uzf NAPHTHOATE SYNTHASE
(Staphylococcus
aureus) 		4 / 8 ILE A 105
ALA A 222
ASP A 240
ILE A 106
 None
 0.78A 5uihA-2uzfA:
undetectable		 5uihA-2uzfA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2uzf NAPHTHOATE SYNTHASE
(Staphylococcus
aureus) 		5 / 7 GLY A 121
GLY A 120
GLY A 144
PRO A 145
GLY A 148
 CAA  A1274 (-3.8A)
CAA  A1274 ( 4.3A)
None
None
None
 0.93A 6ag0A-2uzfA:
undetectable		 6ag0A-2uzfA:
13.31