SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
4 / 5 HIS A  82
ALA A  77
SER A  75
HIS A  45
None
None
None
ZN  A1157 (-3.2A)
1.39A 1errA-2uzhA:
undetectable
1errB-2uzhA:
undetectable
1errA-2uzhA:
19.76
1errB-2uzhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
4 / 8 LEU A 146
VAL A  42
VAL A 129
VAL A  99
None
None
EDO  A1160 (-4.9A)
None
0.93A 1t86A-2uzhA:
undetectable
1t86A-2uzhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 10 ALA A 152
THR A 151
ALA A 150
ALA A  97
VAL A 154
None
0.85A 2f16K-2uzhA:
undetectable
2f16L-2uzhA:
undetectable
2f16K-2uzhA:
21.36
2f16L-2uzhA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 10 ALA A 152
THR A 151
ALA A 150
ALA A  97
VAL A 154
None
0.85A 2f16Y-2uzhA:
undetectable
2f16Z-2uzhA:
undetectable
2f16Y-2uzhA:
21.36
2f16Z-2uzhA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
4 / 7 GLN A  70
PHE A  64
ARG A  68
HIS A  82
None
1.28A 2qmqA-2uzhA:
undetectable
2qmqA-2uzhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
3 / 3 SER A 128
ARG A 112
GLN A 116
EDO  A1160 ( 3.6A)
EDO  A1160 (-4.2A)
EDO  A1160 ( 3.0A)
1.02A 2xnrA-2uzhA:
undetectable
2xnrA-2uzhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
4 / 8 VAL A  42
SER A 120
VAL A 108
VAL A  99
None
GOL  A1161 ( 4.0A)
CDP  A1158 (-4.0A)
None
1.09A 2y05A-2uzhA:
undetectable
2y05B-2uzhA:
undetectable
2y05A-2uzhA:
21.28
2y05B-2uzhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 12 ALA A 152
THR A 151
ALA A 150
ALA A  97
VAL A 154
None
0.86A 3mg0Y-2uzhA:
undetectable
3mg0Z-2uzhA:
undetectable
3mg0Y-2uzhA:
21.36
3mg0Z-2uzhA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 4qvlV-2uzhA:
undetectable
4qvlb-2uzhA:
undetectable
4qvlV-2uzhA:
22.22
4qvlb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 4qvlH-2uzhA:
undetectable
4qvlN-2uzhA:
undetectable
4qvlH-2uzhA:
22.22
4qvlN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 4qvmV-2uzhA:
undetectable
4qvmb-2uzhA:
undetectable
4qvmV-2uzhA:
22.22
4qvmb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qvmH-2uzhA:
undetectable
4qvmN-2uzhA:
undetectable
4qvmH-2uzhA:
22.22
4qvmN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qvpV-2uzhA:
undetectable
4qvpb-2uzhA:
undetectable
4qvpV-2uzhA:
22.22
4qvpb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qvpH-2uzhA:
undetectable
4qvpN-2uzhA:
undetectable
4qvpH-2uzhA:
22.22
4qvpN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qvqV-2uzhA:
undetectable
4qvqb-2uzhA:
undetectable
4qvqV-2uzhA:
22.22
4qvqb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qvqH-2uzhA:
undetectable
4qvqN-2uzhA:
undetectable
4qvqH-2uzhA:
22.22
4qvqN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 4qvwV-2uzhA:
undetectable
4qvwb-2uzhA:
undetectable
4qvwV-2uzhA:
22.22
4qvwb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qvwH-2uzhA:
undetectable
4qvwN-2uzhA:
undetectable
4qvwH-2uzhA:
22.22
4qvwN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 10 ALA A 152
THR A 151
ALA A 150
ALA A  97
VAL A 154
None
0.90A 4qvyK-2uzhA:
undetectable
4qvyL-2uzhA:
undetectable
4qvyK-2uzhA:
21.36
4qvyL-2uzhA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 10 ALA A 152
THR A 151
ALA A 150
ALA A  97
VAL A 154
None
0.89A 4qvyY-2uzhA:
undetectable
4qvyZ-2uzhA:
undetectable
4qvyY-2uzhA:
21.36
4qvyZ-2uzhA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.40A 4qw0V-2uzhA:
undetectable
4qw0b-2uzhA:
undetectable
4qw0V-2uzhA:
22.22
4qw0b-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.40A 4qw0H-2uzhA:
undetectable
4qw0N-2uzhA:
undetectable
4qw0H-2uzhA:
22.22
4qw0N-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 4qw1V-2uzhA:
undetectable
4qw1b-2uzhA:
undetectable
4qw1V-2uzhA:
22.22
4qw1b-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qw1H-2uzhA:
undetectable
4qw1N-2uzhA:
undetectable
4qw1H-2uzhA:
22.22
4qw1N-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qw3V-2uzhA:
undetectable
4qw3b-2uzhA:
undetectable
4qw3V-2uzhA:
22.22
4qw3b-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 4qw3H-2uzhA:
undetectable
4qw3N-2uzhA:
undetectable
4qw3H-2uzhA:
22.22
4qw3N-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.40A 4qwuH-2uzhA:
undetectable
4qwuN-2uzhA:
undetectable
4qwuH-2uzhA:
22.22
4qwuN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.41A 5bxnV-2uzhA:
undetectable
5bxnb-2uzhA:
undetectable
5bxnV-2uzhA:
22.65
5bxnb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.40A 5bxnH-2uzhA:
undetectable
5bxnN-2uzhA:
undetectable
5bxnH-2uzhA:
22.65
5bxnN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.40A 5cz7H-2uzhA:
undetectable
5cz7N-2uzhA:
undetectable
5cz7H-2uzhA:
22.22
5cz7N-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 5d0xV-2uzhA:
undetectable
5d0xb-2uzhA:
undetectable
5d0xV-2uzhA:
22.22
5d0xb-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.42A 5d0xH-2uzhA:
undetectable
5d0xN-2uzhA:
undetectable
5d0xH-2uzhA:
22.22
5d0xN-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.38A 5l66V-2uzhA:
undetectable
5l66b-2uzhA:
undetectable
5l66V-2uzhA:
22.22
5l66b-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.38A 5l66H-2uzhA:
undetectable
5l66N-2uzhA:
undetectable
5l66H-2uzhA:
22.22
5l66N-2uzhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 12 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
None
CDP  A1158 (-2.7A)
CDP  A1158 (-3.3A)
None
None
1.40A 5lf3b-2uzhA:
undetectable
5lf3b-2uzhA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
3 / 3 GLY A 141
THR A 133
ASN A 104
None
CDP  A1158 (-2.7A)
None
0.67A 5odiG-2uzhA:
undetectable
5odiG-2uzhA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
2uzh 2C-METHYL-D-ERYTHRIT
OL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Mycolicibacteriu
m
smegmatis)
5 / 10 VAL A 127
ALA A 125
LEU A 119
LEU A  51
LEU A  47
None
1.00A 6f5uA-2uzhA:
undetectable
6f5uB-2uzhA:
undetectable
6f5uA-2uzhA:
22.52
6f5uB-2uzhA:
20.00