SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 GLN B 464
HIS B 476
PRO B 475
 None
 0.90A 1d8cA-2uzxB:
undetectable		 1d8cA-2uzxB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B 438
VAL B 437
SER B 360
VAL B 486
LEU B 480
 None
 1.28A 2hc4A-2uzxB:
undetectable		 2hc4A-2uzxB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 PRO B 534
ASN B 594
ARG B 591
 None
 1.04A 2qeuB-2uzxB:
undetectable		 2qeuB-2uzxB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 GLU B 493
HIS B  60
GLU B  75
 None
 0.77A 2x45B-2uzxB:
undetectable		 2x45B-2uzxB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 GLU B 493
HIS B  60
GLU B  75
 None
 0.78A 2x45C-2uzxB:
undetectable		 2x45C-2uzxB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ASP B 587
PHE B 588
LEU B 598
 None
 0.57A 2zi9A-2uzxB:
undetectable		 2zi9A-2uzxB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B 438
VAL B 437
SER B 360
VAL B 486
LEU B 480
 None
 1.24A 2zlcA-2uzxB:
undetectable		 2zlcA-2uzxB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.36A 2zweA-2uzxB:
undetectable
2zweB-2uzxB:
undetectable		 2zweA-2uzxB:
18.16
2zweB-2uzxB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.36A 2zwfA-2uzxB:
undetectable
2zwfB-2uzxB:
undetectable		 2zwfA-2uzxB:
18.16
2zwfB-2uzxB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 PRO B 325
LEU B 329
ARG B 469
 None
 0.83A 3aqiA-2uzxB:
undetectable		 3aqiA-2uzxB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 TYR B 321
ILE B 446
VAL B 492
ILE B 452
 None
 0.83A 3p4wC-2uzxB:
undetectable		 3p4wC-2uzxB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 5 THR B 273
PHE B 274
ARG B 266
LEU B 269
 None
 1.44A 3qelC-2uzxB:
undetectable		 3qelC-2uzxB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 LEU B 604
GLY B 606
LEU B 605
GLU B 608
 None
 1.01A 3tgvB-2uzxB:
undetectable		 3tgvB-2uzxB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B 258
TYR B 260
PHE B 253
LEU B 296
LEU B 262
 None
 1.29A 4j03A-2uzxB:
undetectable		 4j03A-2uzxB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 ARG B 218
LEU B 219
ASP B 174
ILE B 161
 None
 1.04A 4k0bA-2uzxB:
undetectable		 4k0bA-2uzxB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_2
(SERUM ALBUMIN)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 VAL B 237
GLU B 293
ASP B 231
LYS B 414
 None
 1.33A 4l9qA-2uzxB:
undetectable		 4l9qA-2uzxB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 LEU B 386
THR B 263
HIS B 388
GLN B 265
ILE B 279
 None
 1.14A 4rp8C-2uzxB:
undetectable		 4rp8C-2uzxB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 PHE B 590
LEU B 562
PRO B 563
ARG B 592
 None
 1.39A 4yv5B-2uzxB:
undetectable		 4yv5B-2uzxB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 6 LEU B 120
VAL B 122
THR B 124
GLU B  83
 None
 0.92A 5tudD-2uzxB:
undetectable		 5tudD-2uzxB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 PHE B 226
ILE B 161
PHE B 195
LEU B 130
HIS B  58
 None
 1.22A 5v5zA-2uzxB:
undetectable		 5v5zA-2uzxB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ARG B 280
PHE B 343
LEU B 296
 None
 0.63A 5veuA-2uzxB:
undetectable		 5veuA-2uzxB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.45A 5z0fA-2uzxB:
undetectable
5z0fB-2uzxB:
undetectable		 5z0fA-2uzxB:
8.48
5z0fB-2uzxB:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.40A 5z0gA-2uzxB:
undetectable
5z0gB-2uzxB:
undetectable		 5z0gA-2uzxB:
8.48
5z0gB-2uzxB:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.41A 5z0iA-2uzxB:
undetectable
5z0iB-2uzxB:
undetectable		 5z0iA-2uzxB:
8.48
5z0iB-2uzxB:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.38A 5z0kA-2uzxB:
undetectable
5z0kB-2uzxB:
undetectable		 5z0kA-2uzxB:
8.48
5z0kB-2uzxB:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 11 HIS B 144
ILE B  70
VAL B 136
SER B 132
PRO B  88
 None
 1.43A 5z0mA-2uzxB:
undetectable
5z0mB-2uzxB:
undetectable		 5z0mA-2uzxB:
8.63
5z0mB-2uzxB:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ASN B 594
VAL B 465
HIS B 476
 None
 0.86A 6a5yD-2uzxB:
undetectable		 6a5yD-2uzxB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 6 PHE B 146
VAL B  72
LEU B 120
LEU B 130
HIS B  58
 None
 1.37A 6e43A-2uzxB:
undetectable		 6e43A-2uzxB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 6 PHE B 146
VAL B  72
LEU B 120
LEU B 130
HIS B  58
 None
 1.38A 6e43B-2uzxB:
undetectable		 6e43B-2uzxB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 6 PHE B 146
VAL B  72
LEU B 120
LEU B 130
HIS B  58
 None
 1.38A 6e43C-2uzxB:
undetectable		 6e43C-2uzxB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 6 PHE B 146
VAL B  72
LEU B 120
LEU B 130
HIS B  58
 None
 1.42A 6e43D-2uzxB:
undetectable		 6e43D-2uzxB:
19.32