SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2uzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		6 / 9 GLU A 190
ARG A 176
ILE A 184
ALA A 196
ILE A   6
THR A 186
 None
 1.42A 1aj6A-2uzzA:
undetectable		 1aj6A-2uzzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 GLU A 190
ARG A 176
ILE A 184
ILE A   6
THR A 186
 None
 1.24A 1kijA-2uzzA:
undetectable		 1kijA-2uzzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 10 GLY A  18
VAL A  28
ALA A 350
ALA A 354
ILE A 197
 None
 0.96A 1likA-2uzzA:
4.0		 1likA-2uzzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 TRP A  71
ILE A  50
VAL A  64
ALA A  17
GLY A 339
 None
None
None
None
FAD  A1373 (-3.2A)
 1.07A 1nbiA-2uzzA:
2.7		 1nbiA-2uzzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 TRP A  71
ILE A  50
VAL A  64
ALA A  17
GLY A 339
 None
None
None
None
FAD  A1373 (-3.2A)
 1.08A 1nbiB-2uzzA:
2.8		 1nbiB-2uzzA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ILE A 136
GLY A  93
GLY A 240
ILE A  90
PRO A 132
 None
 1.03A 1nv8B-2uzzA:
3.0		 1nv8B-2uzzA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 PHE A 318
ALA A  16
LEU A 368
GLY A  14
LEU A 331
 None
 1.09A 1qabF-2uzzA:
undetectable		 1qabF-2uzzA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ILE A 136
GLY A  93
GLY A 240
ILE A  90
PRO A 132
 None
 1.01A 1vq1B-2uzzA:
3.1		 1vq1B-2uzzA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 8 TYR A 135
LYS A 116
GLU A 241
GLY A  93
 None
 1.08A 1ykiA-2uzzA:
undetectable
1ykiB-2uzzA:
undetectable		 1ykiA-2uzzA:
23.10
1ykiB-2uzzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 11 ILE A 299
LEU A 296
GLY A 240
GLY A 137
VAL A 295
 None
 0.98A 2fxdA-2uzzA:
undetectable		 2fxdA-2uzzA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 LEU A 146
GLY A 339
LYS A  59
VAL A  64
ALA A  67
 None
FAD  A1373 (-3.2A)
None
None
None
 1.33A 2kceA-2uzzA:
undetectable		 2kceA-2uzzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 6 ARG A 228
PHE A 235
ILE A 129
PHE A 238
 None
 1.25A 2qeiA-2uzzA:
undetectable		 2qeiA-2uzzA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 7 ILE A   8
ILE A 152
LEU A 207
LEU A 335
 None
None
FAD  A1373 (-3.9A)
FAD  A1373 ( 3.8A)
 0.92A 3adxA-2uzzA:
undetectable		 3adxA-2uzzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 HIS A  38
GLY A  14
ASP A  32
ILE A 197
GLY A 347
 FAD  A1373 (-4.0A)
None
FAD  A1373 (-2.6A)
None
None
 0.87A 3bwcB-2uzzA:
3.2		 3bwcB-2uzzA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		3 / 3 LEU A 207
GLU A 185
ILE A 184
 FAD  A1373 (-3.9A)
None
None
 0.51A 3czhA-2uzzA:
undetectable		 3czhA-2uzzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 8 GLY A 334
GLY A 337
HIS A 338
SER A 313
 None
FAD  A1373 ( 3.7A)
None
None
 0.69A 3d41A-2uzzA:
undetectable		 3d41A-2uzzA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ALA A  16
GLY A  18
GLY A  11
SER A  10
MET A  30
 None
None
FAD  A1373 (-3.4A)
None
None
 1.06A 3ou6A-2uzzA:
2.6		 3ou6A-2uzzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ALA A  16
GLY A  18
GLY A  11
SER A  10
MET A  30
 None
None
FAD  A1373 (-3.4A)
None
None
 1.05A 3ou6B-2uzzA:
2.3		 3ou6B-2uzzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ALA A  16
GLY A  18
GLY A  11
SER A  10
MET A  30
 None
None
FAD  A1373 (-3.4A)
None
None
 1.05A 3ou7A-2uzzA:
2.5		 3ou7A-2uzzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ALA A  16
GLY A  18
GLY A  11
SER A  10
MET A  30
 None
None
FAD  A1373 (-3.4A)
None
None
 1.05A 3ou7B-2uzzA:
undetectable		 3ou7B-2uzzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ALA A  16
GLY A  18
GLY A  11
SER A  10
MET A  30
 None
None
FAD  A1373 (-3.4A)
None
None
 1.04A 3ou7D-2uzzA:
2.2		 3ou7D-2uzzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 TRP A  71
ALA A 151
ASP A  32
GLY A  14
GLY A   9
 None
None
FAD  A1373 (-2.6A)
None
FAD  A1373 (-3.5A)
 1.05A 4hfpB-2uzzA:
undetectable		 4hfpB-2uzzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 5 THR A  31
THR A 329
LEU A 208
LEU A 207
 None
None
None
FAD  A1373 (-3.9A)
 1.10A 4lvcB-2uzzA:
undetectable		 4lvcB-2uzzA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 9 LEU A 208
GLY A 201
ALA A 200
VAL A 172
ILE A 197
 None
FAD  A1373 (-3.4A)
FAD  A1373 (-3.5A)
FAD  A1373 (-3.7A)
None
 1.08A 4njtD-2uzzA:
undetectable		 4njtD-2uzzA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 LEU A 211
GLY A 201
ALA A 200
ALA A 196
ILE A 175
 None
FAD  A1373 (-3.4A)
FAD  A1373 (-3.5A)
None
None
 1.06A 4nkxC-2uzzA:
undetectable		 4nkxC-2uzzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 LEU A 211
GLY A 201
ALA A 200
ALA A 196
ILE A 175
 None
FAD  A1373 (-3.4A)
FAD  A1373 (-3.5A)
None
None
 1.02A 4nkxD-2uzzA:
undetectable		 4nkxD-2uzzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 10 LEU A 363
LEU A 368
LEU A 331
ILE A 332
LEU A 330
 None
 1.04A 4odoB-2uzzA:
undetectable		 4odoB-2uzzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 10 LEU A 363
LEU A 368
LEU A 331
ILE A 332
LEU A 330
 None
 1.04A 4odoC-2uzzA:
undetectable		 4odoC-2uzzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 LEU A  63
GLY A 347
PHE A 342
ALA A  21
ALA A 350
 None
 1.20A 4pclB-2uzzA:
3.2		 4pclB-2uzzA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 GLU A 190
ARG A 176
ILE A 184
ILE A   6
THR A 186
 None
 1.35A 4uroD-2uzzA:
undetectable		 4uroD-2uzzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 8 PHE A 340
TRP A  71
TRP A 155
TYR A  20
 FAD  A1373 (-4.8A)
None
None
None
 1.18A 4v2zC-2uzzA:
undetectable		 4v2zC-2uzzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 TYR A  54
GLY A  57
LEU A 346
GLY A 201
HIS A 338
 None
None
None
FAD  A1373 (-3.4A)
None
 1.24A 4ze1A-2uzzA:
undetectable		 4ze1A-2uzzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		6 / 12 GLY A 339
VAL A  13
ALA A  16
ILE A   7
ALA A 151
PHE A 168
 FAD  A1373 (-3.2A)
FAD  A1373 (-3.8A)
None
None
None
None
 1.48A 5hesB-2uzzA:
undetectable		 5hesB-2uzzA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		3 / 3 THR A  31
THR A 329
LEU A 208
 None
 0.47A 5m66D-2uzzA:
2.8		 5m66D-2uzzA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		4 / 7 PHE A 366
ASP A 317
PHE A 318
HIS A 338
 None
 1.00A 5n9xA-2uzzA:
undetectable		 5n9xA-2uzzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		3 / 3 TYR A  54
LEU A  63
ASP A 362
 None
 0.78A 5zv2B-2uzzA:
undetectable		 5zv2B-2uzzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 LEU A 346
GLY A  14
ILE A   7
ILE A 320
ILE A 332
 None
 1.00A 6emuA-2uzzA:
2.1		 6emuA-2uzzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE
(Escherichia
coli) 		5 / 12 ILE A   8
GLY A   9
GLY A  11
ALA A  16
VAL A 172
 None
FAD  A1373 (-3.5A)
FAD  A1373 (-3.4A)
None
FAD  A1373 (-3.7A)
 0.70A 6iftA-2uzzA:
2.9		 6iftA-2uzzA:
22.11