SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2v0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42
(Saccharomyces
cerevisiae) 		5 / 11 PRO A 141
LEU A 146
VAL A 128
GLY A 129
TYR A 147
 None
 1.33A 1fkpA-2v0pA:
undetectable		 1fkpA-2v0pA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 146
VAL A 128
GLY A 129
TYR A 147
 None
 0.98A 1lweA-2v0pA:
undetectable		 1lweA-2v0pA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  19
LEU A  82
PHE A 111
SER A 110
ILE A  12
 None
 1.21A 4dm8A-2v0pA:
undetectable		 4dm8A-2v0pA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 208
SER A 212
THR A 116
ASP A 120
 None
 1.07A 4drjB-2v0pA:
2.9		 4drjB-2v0pA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42
(Saccharomyces
cerevisiae) 		4 / 7 THR A 215
LEU A  42
LYS A  40
LEU A  35
 None
 1.05A 4ib4A-2v0pA:
3.7		 4ib4A-2v0pA:
22.56